Department of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan.
Neurosci Lett. 2013 May 24;543:168-71. doi: 10.1016/j.neulet.2013.03.049. Epub 2013 Apr 9.
Optimal functional recovery after stroke is the most important to improve quality of life. Contralateral hemisphere of infarction site plays an important role for the recovery. The underlying processes in contralateral hemisphere during recovery have not yet been fully elucidated. We have previously reported the increase in synaptic turnover in the contralateral somatosensory cortex (SSC) during 1st week after infarction of the unilateral SSC. The neuronal circuit was remodeled after this period to process bilateral information in the remaining hemisphere, and functional compensation was achieved. In the present study, we used in vivo electrophysiological recording to detect the current source density (CSD) for somatosensory input. Interestingly, a specific CSD pattern was detected in the layer II/III region of contralateral SSC and the duration was significantly correlated with functional recovery. These results indicate that the compensational remodeling of neuronal circuit in the intact hemisphere may be dominantly induced in layer II/III neurons.
脑卒中后最佳的功能恢复对于提高生活质量非常重要。对梗死部位对侧大脑半球的利用发挥了重要作用。但对侧大脑半球在恢复过程中的潜在机制尚未完全阐明。我们之前曾报道过，在单侧大脑感觉皮层（SSC）梗死 1 周后，对侧感觉皮层（SSC）中的突触周转率增加。在此期间，神经元回路进行了重塑，以处理剩余大脑半球中的双侧信息，并实现了功能代偿。在本研究中，我们使用活体电生理记录来检测体感输入的电流源密度（CSD）。有趣的是，在对侧 SSC 的 II/III 层中检测到特定的 CSD 模式，且其持续时间与功能恢复显著相关。这些结果表明，完整大脑半球中神经元回路的代偿性重塑可能主要由 II/III 层神经元诱导。
