Obi Kisho, Amano Izuki, Takatsuru Yusuke
Department of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan.
Department of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan.
Brain Res. 2018 Jan 1;1678:146-152. doi: 10.1016/j.brainres.2017.10.022. Epub 2017 Oct 24.
Functional recovery after a stroke is important for patients' quality of life. Not only medical care during the acute phase, but also rehabilitation during the chronic phase after a stroke is important. However, the mechanisms underlying functional recovery, particularly the chronic phase after stroke, are still not fully understood. Thus, further basic study on brain after focal stroke is necessary. In this study, we found that the concentration of dopamine (DA) increased during first week after a stroke in the hemisphere contralateral in the site of stroke by in vivo microdialysis. When we applied haloperidol (HPD), a potent DA receptor blocker, functional recovery was inhibited. Interestingly, administration of aripiprazole (ARP), a novel partial agonist of the DA receptor, during the chronic phase improved the remodeling of neuronal circuits in somatosensory cortex (SSC). These findings indicate that the DAergic system play a critical role in functional compensation by the non-infarcted hemisphere after a focal stroke in SSC. It is also revealed that administration of HPD/ARP to stroke patients affects functional recovery after a stroke, and stimulation of the DAergic system during the chronic phase of stroke potentially benefits stroke patients.
中风后的功能恢复对患者的生活质量很重要。不仅急性期的医疗护理重要，中风后慢性期的康复也很重要。然而，功能恢复的潜在机制，尤其是中风后的慢性期，仍未完全了解。因此，有必要对局灶性中风后的大脑进行进一步的基础研究。在本研究中，我们通过体内微透析发现，中风后第一周，中风部位对侧半球的多巴胺（DA）浓度升高。当我们应用强效DA受体阻滞剂氟哌啶醇（HPD）时，功能恢复受到抑制。有趣的是，在慢性期给予新型DA受体部分激动剂阿立哌唑（ARP）可改善体感皮层（SSC）神经元回路的重塑。这些发现表明，DA能系统在SSC局灶性中风后非梗死半球的功能代偿中起关键作用。还揭示了对中风患者给予HPD/ARP会影响中风后的功能恢复，并且在中风慢性期刺激DA能系统可能使中风患者受益。
