Flaer Paul J, Cistone Peter J, Younis Mustafa Z, Parkash Jai
Diagnosis and Treatment Planning Section, AEGD Residency Program of Community Smiles, Dade County Dental Research Clinic, Miami, FL, USA.
Eval Program Plann. 2013 Aug;39:23-7. doi: 10.1016/j.evalprogplan.2013.03.004. Epub 2013 Mar 18.
The purpose of this study was to produce models composed of mapping of connectivity networks of HIV transmission risk in injection drug users (IDUs). This methodology provided a novel approach and diagnostic tool for understanding HIV infection transmission risk and drug use in the typical niche of IDUs, i.e., a "shooting gallery" (a gathering site for injection drug activity). Furthermore, component IDUs may have memberships in multiple "shooting galleries" revealing subsequent interconnectivities. Charting of IDU connectivity diagrams illustrated the relationships of peripheral sites to the critical central core of high HIV transmission risk. Members of this highly interlinked and infectious central core of IDUs had high HIV transmission risk and severe drug use-producing high morbidity and mortality that resulted in great public health concern. In addition, connectivity diagrams reveal very high HIV transmission risk in component IDUs in "dual memberships", i.e., membership in more than one central core (with the highest number of partners). Therefore, IDUs with "dual memberships" were the most infectious members of the "shooting gallery". In summation, network mapping of HIV transmission risk in IDUs allows for subsequent socio-behavioral analysis and the development of focused individual and programmatic interventions.
本研究的目的是生成由注射吸毒者（IDU）中HIV传播风险连接网络映射组成的模型。这种方法为理解IDU典型场所（即“射击场”，一个注射吸毒活动的聚集地点）中的HIV感染传播风险和吸毒情况提供了一种新颖的方法和诊断工具。此外，个体IDU可能隶属于多个“射击场”，这揭示了后续的相互联系。绘制IDU连接图说明了周边场所与HIV高传播风险关键中心核心的关系。这个高度相互关联且具有传染性的IDU中心核心成员具有高HIV传播风险和严重吸毒问题，导致高发病率和死亡率，引起了极大的公共卫生关注。此外，连接图显示在“双重隶属”的个体IDU中，即隶属于多个中心核心（性伴数量最多）的IDU中，HIV传播风险非常高。因此，具有“双重隶属”的IDU是“射击场”中最具传染性的成员。总之，IDU中HIV传播风险的网络映射有助于后续的社会行为分析以及制定有针对性的个体和项目干预措施。
