• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

NPMc+ and FLT3_ITD mutations cooperate in inducing acute leukaemia in a novel mouse model.

作者信息

Mallardo M, Caronno A, Pruneri G, Raviele P R, Viale A, Pelicci P G, Colombo E

机构信息

Department of Experimental Oncology, European Institute of Oncology, Milan, Italy.

出版信息

Leukemia. 2013 Nov;27(11):2248-51. doi: 10.1038/leu.2013.114. Epub 2013 Apr 15.

DOI:10.1038/leu.2013.114
PMID:23584564
Abstract
摘要

相似文献

1
NPMc+ and FLT3_ITD mutations cooperate in inducing acute leukaemia in a novel mouse model.在一种新型小鼠模型中，NPMc+和FLT3_ITD突变协同诱导急性白血病。
Leukemia. 2013 Nov;27(11):2248-51. doi: 10.1038/leu.2013.114. Epub 2013 Apr 15.
2
FLT3-ITD expression levels and their effect on STAT5 in AML with and without NPM mutations.FLT3-ITD 表达水平及其对伴有和不伴有 NPM 突变的 AML 中 STAT5 的影响。
Br J Haematol. 2009 Dec;147(5):653-61. doi: 10.1111/j.1365-2141.2009.07901.x. Epub 2009 Sep 22.
3
Influence of FLT3-internal tandem duplication allele burden and white blood cell count on the outcome in patients with intermediate-risk karyotype acute myeloid leukemia.FLT3 内部串联重复等位基因负担和白细胞计数对中危核型急性髓系白血病患者结局的影响。
Cancer. 2012 Dec 15;118(24):6110-7. doi: 10.1002/cncr.27683. Epub 2012 Jun 26.
4
Meta-analysis for the potential application of FLT3-TKD mutations as prognostic indicator in non-promyelocytic AML.FLT3-TKD 突变作为非早幼粒细胞性急性髓系白血病预后指标的潜在应用的荟萃分析。
Leuk Res. 2012 Feb;36(2):186-91. doi: 10.1016/j.leukres.2011.08.014. Epub 2011 Sep 9.
5
Clinical impact of nucleophosmin mutations and Flt3 internal tandem duplications in patients older than 60 yr with acute myeloid leukaemia.60岁以上急性髓系白血病患者中核磷蛋白突变和Flt3内部串联重复的临床影响
Eur J Haematol. 2008 Mar;80(3):208-15. doi: 10.1111/j.1600-0609.2007.01019.x.
6
Flt3-ITD mutations in a mouse model of radiation-induced acute myeloid leukaemia.辐射诱导的急性髓系白血病小鼠模型中的Flt3-ITD突变
Leukemia. 2012 Jun;26(6):1445-6. doi: 10.1038/leu.2011.377. Epub 2012 Jan 6.
7
[Prevalence and clinical significance of FLT3 internal tandem duplication mutation in acute leukemia].[急性白血病中FLT3内部串联重复突变的患病率及临床意义]
Zhonghua Xue Ye Xue Za Zhi. 2004 Jul;25(7):393-6.
8
The genotype nucleophosmin mutated and FLT3-ITD negative is characterized by high bax/bcl-2 ratio and favourable outcome in acute myeloid leukaemia.基因型核仁磷酸蛋白突变且 FLT3-ITD 阴性的急性髓系白血病具有高 bax/bcl-2 比值和良好的预后。
Br J Haematol. 2010 May;149(3):383-7. doi: 10.1111/j.1365-2141.2010.08098.x. Epub 2010 Feb 8.
9
CEBPA single mutation can be a possible favorable prognostic indicator in NPM1 and FLT3-ITD wild-type acute myeloid leukemia patients with intermediate cytogenetic risk.CEBPA 单突变可能是中危细胞遗传学核型伴有 NPM1 和 FLT3-ITD 野生型急性髓系白血病患者的有利预后指标。
Leuk Res. 2013 Nov;37(11):1488-94. doi: 10.1016/j.leukres.2013.08.014. Epub 2013 Sep 5.
10
Evolution of FLT3-ITD and D835 activating point mutations in relapsing acute myeloid leukemia and response to salvage therapy.复发急性髓系白血病中FLT3-ITD和D835激活点突变的演变及对挽救治疗的反应
Leuk Res. 2004 Oct;28(10):1069-74. doi: 10.1016/j.leukres.2004.02.009.

引用本文的文献

1
Mutant cooperates with or to drive distinct myeloid diseases and molecular outcomes.突变体协同或驱动不同的髓系疾病及分子结果。
Proc Natl Acad Sci U S A. 2025 May 20;122(20):e2415779122. doi: 10.1073/pnas.2415779122. Epub 2025 May 16.
2
Targeting leukemic stem cell dormancy in --driven acute myeloid leukemia.靶向在--驱动的急性髓系白血病中的白血病干细胞休眠
Haematologica. 2025 Sep 1;110(9):1900-1902. doi: 10.3324/haematol.2025.287644. Epub 2025 May 8.
3
Enforcement of stem-cell dormancy by nucleophosmin mutation is a critical determinant of unrestricted self-renewal during myeloid leukemogenesis.
核磷蛋白突变导致的干细胞休眠是髓系白血病发生过程中不受限制的自我更新的关键决定因素。
Haematologica. 2025 Mar 13. doi: 10.3324/haematol.2024.286577.
4
Functions of the native NPM1 protein and its leukemic mutant.天然NPM1蛋白及其白血病突变体的功能。
Leukemia. 2025 Feb;39(2):276-290. doi: 10.1038/s41375-024-02476-4. Epub 2024 Dec 17.
5
Caloric restriction leads to druggable LSD1-dependent cancer stem cells expansion.热量限制导致可药物靶向的依赖赖氨酸特异性去甲基化酶1的癌症干细胞扩增。
Nat Commun. 2024 Jan 27;15(1):828. doi: 10.1038/s41467-023-44348-y.
6
NPM1 mutation reprograms leukemic transcription network via reshaping TAD topology.NPM1 突变通过重塑 TAD 拓扑结构重新编程白血病转录网络。
Leukemia. 2023 Aug;37(8):1732-1736. doi: 10.1038/s41375-023-01942-9. Epub 2023 Jun 26.
7
FLT3ITD drives context-specific changes in cell identity and variable interferon dependence during AML initiation.FLT3ITD 在 AML 起始过程中驱动细胞身份的特定上下文变化和可变干扰素依赖性。
Blood. 2023 Mar 23;141(12):1442-1456. doi: 10.1182/blood.2022016889.
8
Dissecting the Genetic and Non-Genetic Heterogeneity of Acute Myeloid Leukemia Using Next-Generation Sequencing and In Vivo Models.利用新一代测序技术和体内模型剖析急性髓系白血病的遗传和非遗传异质性
Cancers (Basel). 2022 Apr 27;14(9):2182. doi: 10.3390/cancers14092182.
9
Mouse Models of Frequently Mutated Genes in Acute Myeloid Leukemia.急性髓系白血病中常见突变基因的小鼠模型
Cancers (Basel). 2021 Dec 8;13(24):6192. doi: 10.3390/cancers13246192.
10
Statistical tests for intra-tumour clonal co-occurrence and exclusivity.统计检验肿瘤内克隆共存和排他性。
PLoS Comput Biol. 2021 Dec 15;17(12):e1009036. doi: 10.1371/journal.pcbi.1009036. eCollection 2021 Dec.