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Flt3-ITD mutations in a mouse model of radiation-induced acute myeloid leukaemia.

作者信息

Finnon R, Brown N, Moody J, Badie C, Olme C-H, Huiskamp R, Meijne E, Sutmuller M, Rosemann M, Bouffler S D

出版信息

Leukemia. 2012 Jun;26(6):1445-6. doi: 10.1038/leu.2011.377. Epub 2012 Jan 6.

DOI:10.1038/leu.2011.377
PMID:22289922
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3377996/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a76/3377996/51ae1cdb38a6/leu2011377f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a76/3377996/51ae1cdb38a6/leu2011377f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a76/3377996/51ae1cdb38a6/leu2011377f1.jpg

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本文引用的文献

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Sfpi1/PU.1 mutations in mouse radiation-induced acute myeloid leukaemias affect mRNA and protein abundance and associate with disrupted transcription.Sfpi1/PU.1 突变在小鼠辐射诱导的急性髓系白血病中影响 mRNA 和蛋白质丰度，并与转录失调相关。
Leuk Res. 2011 Jan;35(1):126-32. doi: 10.1016/j.leukres.2010.06.015. Epub 2010 Jul 17.
2
Radiation leukemogenesis in mice: loss of PU.1 on chromosome 2 in CBA and C57BL/6 mice after irradiation with 1 GeV/nucleon 56Fe ions, X rays or gamma rays. Part I. Experimental observations.小鼠辐射诱发白血病：用1 GeV/核子的56Fe离子、X射线或γ射线照射后，CBA和C57BL/6小鼠2号染色体上PU.1的缺失。第一部分。实验观察。
Radiat Res. 2009 Apr;171(4):474-83. doi: 10.1667/RR1547.1.
3
R235C点突变使小鼠对辐射诱导的急性髓系白血病敏感。
iScience. 2023 Aug 3;26(9):107530. doi: 10.1016/j.isci.2023.107530. eCollection 2023 Sep 15.
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Leukemic stem cells and advances in hematopoietic stem cell transplantation for acute myeloid leukemia: a narrative review of clinical trials.白血病干细胞与急性髓系白血病造血干细胞移植的进展：临床试验的叙述性综述
Stem Cell Investig. 2022 Dec 5;9:10. doi: 10.21037/sci-2022-044. eCollection 2022.
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Radiat Environ Biophys. 2022 Aug;61(3):361-373. doi: 10.1007/s00411-022-00981-7. Epub 2022 Jul 21.
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FLT3 mutations: biology and treatment.
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Hematology Am Soc Hematol Educ Program. 2006:178-84. doi: 10.1182/asheducation-2006.1.178.
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Mutations of the PU.1 Ets domain are specifically associated with murine radiation-induced, but not human therapy-related, acute myeloid leukaemia.PU.1 Ets结构域的突变与小鼠辐射诱导的急性髓系白血病特异性相关，但与人类治疗相关的急性髓系白血病无关。
Oncogene. 2005 May 19;24(22):3678-83. doi: 10.1038/sj.onc.1208422.
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The roles of FLT3 in hematopoiesis and leukemia.FLT3在造血作用和白血病中的作用。
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Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product.
Leukemia. 1998 Sep;12(9):1333-7. doi: 10.1038/sj.leu.2401130.