Kevere Laura, Purvina Santa, Bauze Daiga, Zeibarts Marcis, Andrezina Raisa, Piekuse Linda, Brekis Edgars, Purvins Indulis
Laura Kevere, Department of Psychiatry, Riga Stradins University , Riga , Latvia.
Nord J Psychiatry. 2014 Feb;68(2):129-36. doi: 10.3109/08039488.2013.782066. Epub 2013 Apr 16.
High level of homocysteine (Hcy) is risk factor of schizophrenia and mood disorders.
The aim was to detect a serum level of Hcy, examine the associations between the level of Hcy, methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism and clinical properties for patients with schizophrenia, mood disorders and in a control group.
There were 88 patients with schizophrenia, 28 with affective disorders and 94 from the control group. The Hamilton Anxiety Scale (HAM-A) was performed to study anxiety, the Hamilton Depression Scale (HAM-D) to study depression and the Brief Psychiatric Rating Scale (BPRS) to study severity of schizophrenia. The level of Hcy was stated by isocratic high-performance liquid chromatography (HPLC) system with fluorometric detection. DNA isolation from venous blood was performed by the phenol-chloroform method.
The levels of B12 vitamin and folic acid were within normal limits for all the patients. The average level of Hcy was 11.94 ± 5.6 μmol/l for patients with schizophrenia and 11.65 ± 3.3 μmol/l for patients with affective disorders, vs. 6.80 ± 2.93 μmol/l in a control group. The highest level of Hcy has been observed in patients with an episodic-recurrent course of schizophrenia, paranoid schizophrenia-continuous, particularly in patients with CT genotype (r = - 0.58; P < 0.01). In the given diagnostic groups, the highest level of anxiety was observed.
The level of Hcy is higher in the blood of a heterozygotic person who becomes ill with schizophrenia, and the process of the illness is more serious and with more typical affective disorders.
高同型半胱氨酸（Hcy）水平是精神分裂症和情绪障碍的危险因素。
检测血清Hcy水平，研究精神分裂症、情绪障碍患者及对照组中Hcy水平、亚甲基四氢叶酸还原酶（MTHFR）基因C677T多态性与临床特征之间的关联。
精神分裂症患者88例，情感障碍患者28例，对照组94例。采用汉密尔顿焦虑量表（HAM - A）评估焦虑，汉密尔顿抑郁量表（HAM - D）评估抑郁，简明精神病评定量表（BPRS）评估精神分裂症严重程度。采用等度高效液相色谱（HPLC）系统荧光检测法测定Hcy水平。采用酚 - 氯仿法从静脉血中提取DNA。
所有患者的维生素B12和叶酸水平均在正常范围内。精神分裂症患者的Hcy平均水平为11.94±5.6μmol/l，情感障碍患者为11.65±3.3μmol/l，而对照组为6.80±2.93μmol/l。在发作 - 复发型精神分裂症、偏执型精神分裂症持续型患者中，尤其是CT基因型患者，Hcy水平最高（r = - 0.58；P < 0.01）。在这些诊断组中，观察到最高水平的焦虑。
患精神分裂症的杂合子个体血液中Hcy水平较高，且疾病过程更严重，伴有更典型的情感障碍。
