Hoheisel G, Petter H
Sektion Biowissenschaften, Karl-Marx-Universität Leipzig, DDR.
J Hirnforsch. 1990;31(2):201-14.
In both species of lacertilian reptiles investigated, the peptidergic hypothalamic supraoptic and paraventricular nucleus project with efferents to the telencephalon, to caudal parts of the brain, and to the spinal cord. The marked system of efferents of the "classic" peptidergic neurosecretory nuclei to the telencephalon was mapped. The unlabeled peroxidase-antiperoxidase immunocytochemical procedure revealed at the light microscopical level neurophysin- respectively mesotocin- or vasotocin-containing exohypothalamic fibres in the septal area, in subcortical regions (ventral striatum and hypopallium), and in all layers of the cortical areas (medial, dorsal and lateral cortex). Within the different parts of the brain, there seems to be a characteristically quantitative ratio of the mesotocin and vasotocin fibres. The terminals of the exohypothalamic fibres contact perikarya and processes of neurons of the target regions intimately. In a selected area, peptidergic synapses could be demonstrated at the electron microscopical level using an ultrahistochemical method. It is assumed that the nonapeptides mentioned are released from the fibre terminals and then act as neurotransmitters/neuromodulators influencing different brain functions.
在所研究的两种蜥蜴类爬行动物中，肽能下丘脑视上核和室旁核发出的传出纤维投射到端脑、脑的尾部以及脊髓。绘制了“经典”肽能神经分泌核到端脑的显著传出系统图谱。未标记的过氧化物酶-抗过氧化物酶免疫细胞化学方法在光学显微镜水平揭示，在隔区、皮质下区域（腹侧纹状体和下皮质）以及皮质区域的所有层（内侧、背侧和外侧皮质）中存在分别含有神经垂体素、中催产素或血管催产素的下丘脑外纤维。在脑的不同部位，中催产素和血管催产素纤维似乎存在特征性的数量比例。下丘脑外纤维的终末与靶区域神经元的胞体和突起紧密接触。在一个选定区域，使用超组织化学方法在电子显微镜水平证实了肽能突触的存在。据推测，上述九肽从纤维终末释放，然后作为神经递质/神经调质影响不同的脑功能。
