University of Iowa Hospitals and Clinics, Department of Pathology, USA.
Brain Pathol. 2013 May;23(3):365-6. doi: 10.1111/bpa.12053.
Hepatocellular carcinoma rarely metastasizes to the pituitary gland and this site is very rarely the initial site of disease presentation. When it does, it may mimic a far more common pituitary adenoma. Metastatic hepatocellular carcinoma should be suspected in any individual with known liver disease or significant risk factors. The most common clinical sign of metastatic HCC to the skull is a subcutaneous mass followed by neurological deficits including visual disturbances, headache and seizure. The diagnosis can be made based on the histopathologic and immunohistochemical findings. When metastatic HCC is present in the skull base, appropriate work up should be done to rule out other metastatic sites, most commonly present in the spine.
肝细胞癌很少转移到垂体，而且这个部位很少是疾病首发部位。当它转移到垂体时，可能会类似于更常见的垂体腺瘤。对于有已知肝脏疾病或显著危险因素的个体，应怀疑是否患有转移性肝细胞癌。转移性 HCC 转移至颅骨最常见的临床征象是皮下肿块，随后出现神经功能缺损，包括视觉障碍、头痛和癫痫。可以根据组织病理学和免疫组织化学发现做出诊断。当颅骨底部存在转移性 HCC 时，应进行适当的检查以排除其他转移部位，最常见的转移部位是脊柱。
