Haouach Khalil, Tazi Ilias, Mahmal Lahoussin
Service d'hématologie, CHU Mohamed VI, Université Cadi Ayyad, Marrakech, Morocco.
Ann Biol Clin (Paris). 2013 Mar-Apr;71(2):181-4. doi: 10.1684/abc.2013.0792.
T-cell prolymphocytic leukemia is a lymphoid hematologic malignancy of T origin, mature, individualized well by the clinical, morphological, and immunophenotypic as well as cytogenetic aspects. We report the case of a 39-year-old man admitted in our department because of a spinal cord compression. The cerebrospinal fluid analysis had revealed an increased albuminemia level; MRI evoked a vertebral infiltration by a malignancy. Evolution was characterized by the appearance of a tumor syndrome and a peripheral lymphocytosis. Immunophenotyping and the lymph node biopsy concluded of a diagnosis of a T-cell prolymphocytic leukemia. To our knowledge, we report here the first case of T-cell prolymphocytic leukemia revealed by a spinal cord compression.
T细胞原淋巴细胞白血病是一种起源于T细胞的淋巴造血系统恶性肿瘤，在临床、形态学、免疫表型以及细胞遗传学方面都有成熟且独特的表现。我们报告了一例39岁男性因脊髓压迫入住我科的病例。脑脊液分析显示白蛋白血症水平升高；磁共振成像提示有恶性肿瘤浸润椎体。病情进展表现为出现肿瘤综合征和外周淋巴细胞增多。免疫表型分析及淋巴结活检确诊为T细胞原淋巴细胞白血病。据我们所知，本文报告了首例以脊髓压迫为首发表现的T细胞原淋巴细胞白血病病例。
