Rinaudo-Gaujous Mélanie, Talagrand Emilie, Verhoeven Paul O, Garraud Olivier, Flourié Françoise
Laboratoire d'immunologie, CHU Saint-Etienne, France.
Ann Biol Clin (Paris). 2013 Mar-Apr;71(2):215-8. doi: 10.1684/abc.2013.0802.
Pediatric hemolytic uremic syndrome (HUS) is a rare complication of infections usually caused by Escherichia coli; Streptococcus pneumoniae may be a causative agent in 5% of cases and is often more serious in terms of morbidity and mortality. We report a case of pediatric HUS following an infection by a serotype of S. pneumoniae not included in the vaccine administered to the child. Bacterial neuraminidase revealed a T-antigen and a Tk-antigen and red blood cells polyagglutinability in the laboratory test. Transfusion has been reoriented by an indication of secondary preparations: deplasmatisation of red blood cells and platelets and abstention of therapeutic plasma administration. HUS evolved favorably in a few days but the child retains consequences of meningitis cerebral anoxia.
小儿溶血性尿毒症综合征（HUS）是感染的一种罕见并发症，通常由大肠杆菌引起；肺炎链球菌可能在5%的病例中作为病原体，且在发病率和死亡率方面往往更为严重。我们报告一例小儿HUS病例，其感染的肺炎链球菌血清型未包含在给该患儿接种的疫苗中。实验室检测显示细菌神经氨酸酶有T抗原和Tk抗原以及红细胞多凝集性。输血已根据二级制剂的指征进行调整：红细胞和血小板去血浆化以及避免输注治疗性血浆。HUS在数天内病情好转，但患儿仍留有脑膜炎脑缺氧的后遗症。
