Diagnostic Imaging and Neurology, Research Institute, The Hospital for Sick Children, Canada.
Neuroimage. 2013 Sep;78:159-75. doi: 10.1016/j.neuroimage.2013.04.014. Epub 2013 Apr 13.
Evidence from electrophysiological and functional neuroimaging studies has suggested strong lateralization of affective processing within the insular cortices; however, little is known about the spatial location of these processes in these regions. Using quantitative meta-analytic methods the laterality of: (1) emotional processing; (2) stimulus valence (positive vs. negative); (3) perception vs. experience of emotion; and (4) sex-differences were assessed using the data from 143 functional magnetic resonance imaging studies. Activation in response to all emotional stimuli occurred in bilateral anterior and mid-insula, and the left posterior insula. Positive emotional stimuli were associated with activation in the left anterior and mid-insula, while negative emotional stimuli activated bilateral anterior and mid-insula. Activation in response to the perception and experience of emotions was highest in bilateral anterior insula, and within the mid and posterior insula it was left lateralized. In males, emotional stimuli predominantly activated the left anterior/mid-insula and right posterior insula, whereas females activated bilateral anterior insula and the left mid and posterior insula. Spatial distinctions observed in emotional processing and its subcategories can provide a comprehensive account of the role of the insular cortices in affect processing, which could aid in understanding deficits seen in psychiatric or developmental disorders.
来自于电生理学和功能神经影像学的研究证据表明，情绪处理在脑岛皮质中存在强烈的偏侧化；然而，对于这些区域中这些过程的空间位置知之甚少。使用定量元分析方法，评估了以下数据的偏侧性：(1)情绪处理；(2)刺激效价（正性与负性）；(3)情绪的知觉与体验；以及(4)性别差异。来自 143 项功能磁共振成像研究的数据表明，所有情绪刺激的反应都发生在双侧前岛叶和中岛叶，以及左侧后岛叶。正性情绪刺激与左侧前岛叶和中岛叶的激活有关，而负性情绪刺激则激活双侧前岛叶和中岛叶。情绪的知觉和体验的反应在双侧前岛叶最高，而在中岛叶和后岛叶中则是左侧偏侧化。在男性中，情绪刺激主要激活左侧前/中岛叶和右侧后岛叶，而女性则激活双侧前岛叶和左侧中岛叶和后岛叶。在情绪处理及其子类别中观察到的空间差异可以提供对脑岛皮质在情感处理中的作用的全面解释，这有助于理解在精神或发育障碍中观察到的缺陷。
