敲低 ZFX 通过下调 ERK-MAPK 通路抑制体外和体内胃癌细胞生长。
Knockdown of ZFX inhibits gastric cancer cell growth in vitro and in vivo via downregulating the ERK-MAPK pathway.
机构信息
GI Division, Shanghai Jiao-Tong University School of Medicine Renji Hospital, Shanghai Institution of Digestive Disease, Shanghai 200001, China.
出版信息
Cancer Lett. 2013 Sep 1;337(2):293-300. doi: 10.1016/j.canlet.2013.04.003. Epub 2013 Apr 13.
Zinc finger protein X-linked (ZFX) is a zinc finger transcription factor encoded on the X chromosome. Here, we found that ZFX expression was significantly upregulated in gastric cancer (GC) cell lines and tissues. Knockdown of ZFX induced significant apoptosis and cell cycle arrest in SGC7901 and MGC803 cells. Moreover, we demonstrated for the first time that knockdown of ZFX inhibited gastric cancer cell growth in vitro and in vivo via downregulating the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK-MAPK) pathway. Therefore, ZFX play a prominent role in GC tumorigenicity and may have potential applications in the diagnosis or treatment of GC.
X 连锁锌指蛋白（ZFX）是一种锌指转录因子，编码在 X 染色体上。在这里，我们发现 ZFX 在胃癌（GC）细胞系和组织中表达显著上调。ZFX 的敲低诱导 SGC7901 和 MGC803 细胞中发生显著的细胞凋亡和细胞周期停滞。此外，我们首次证明，通过下调细胞外信号调节激酶/丝裂原活化蛋白激酶（ERK-MAPK）通路，ZFX 的敲低抑制了体外和体内的胃癌细胞生长。因此，ZFX 在 GC 肿瘤发生中起重要作用，可能在 GC 的诊断或治疗中有潜在的应用。
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