Ali Waleed, Xiao Weirui, Hoang Henry, Cali Vincent, Kajdacsy-Balla Andre
Albert Einstein College of Medicine, The Bronx, NY 10461, USA.
Department of Pathology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA.
Curr Issues Mol Biol. 2023 Nov 24;45(12):9422-9430. doi: 10.3390/cimb45120591.
Protein arginine methylation is among the most important post-translational modifications and has been studied in cancers such as those of the lung and breast. However, comparatively less has been investigated regarding hepatocellular carcinoma, with an annual incidence of almost one million cases. Through using in silico methods, this study examined arginine methylation-related gene expression and methylation levels, and alongside network and enrichment analysis attempted to find how said genes can drive tumorigenesis and offer possible therapeutic targets. We found a robust relationship among the selected methylation genes, with ⅞ showing prognostic value regarding overall survival, and a medley of non-arginine methylation pathways also being highlighted through the aforementioned analysis. This study furthers our knowledge of the methylation and expression patterns of arginine histone methylation-related genes, offering jumping points for further wet-lab studies.
蛋白质精氨酸甲基化是最重要的翻译后修饰之一，已在肺癌和乳腺癌等癌症中得到研究。然而，关于肝细胞癌的研究相对较少，其年发病率近100万例。通过使用计算机方法，本研究检测了精氨酸甲基化相关基因的表达和甲基化水平，并通过网络和富集分析试图找出这些基因如何驱动肿瘤发生并提供可能的治疗靶点。我们发现所选甲基化基因之间存在密切关系，其中7/8对总生存期具有预后价值，上述分析还突出了一系列非精氨酸甲基化途径。本研究进一步加深了我们对精氨酸组蛋白甲基化相关基因甲基化和表达模式的了解，为进一步的湿实验室研究提供了切入点。
