Department of Psychiatry, College of Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea.
Int Clin Psychopharmacol. 2013 Jul;28(4):184-92. doi: 10.1097/YIC.0b013e3283612509.
We evaluated the effect of osmotic-release oral system (OROS) methylphenidate on learning skills in adolescents with attention-deficit/hyperactivity disorder (ADHD). In an open-label study, 121 adolescents with ADHD were administered flexible doses of OROS methylphenidate for 12 weeks. The efficacy of methylphenidate on ADHD symptoms was evaluated by ADHD Rating Scale (ARS) and Clinical Global Impression Scale (CGI). Learning Skills Test (LST) was used to measure the learning skills of the participants at the baseline and the endpoint. Continuous performance test, visuospatial and verbal working memory, verbal fluency, and inhibition were evaluated before and after the 12 weeks of treatment. The mean total and subscores of LST were significantly increased after the 12-week treatment with OROS methylphenidate. Executive functions were also improved during the trial, with the exception of inhibition measured by the Stroop Test. To the best of our knowledge, this is the first study to examine the influence of OROS methylphenidate on learning skill. As a result, OROS methylphenidate was effective in enhancing learning skills in adolescents with ADHD.
我们评估了渗透型控释片（OROS）哌甲酯对注意缺陷多动障碍（ADHD）青少年学习技能的影响。在一项开放性研究中，121 名 ADHD 青少年接受了为期 12 周的 OROS 哌甲酯的灵活剂量治疗。ADHD 症状的疗效通过 ADHD 评定量表（ARS）和临床总体印象量表（CGI）进行评估。学习技能测试（LST）用于测量参与者在基线和终点的学习技能。在治疗前和治疗 12 周后评估连续性能测试、视空间和言语工作记忆、言语流畅性和抑制。经过 12 周 OROS 哌甲酯治疗后，LST 的总分和子评分显著提高。在试验过程中，执行功能也得到了改善，除了通过斯特鲁普测试测量的抑制。据我们所知，这是第一项研究 OROS 哌甲酯对学习技能的影响。结果表明，OROS 哌甲酯可有效提高 ADHD 青少年的学习技能。
