Dermatology Department. University of Modena and Reggia Emilia, Modena, Italy.
G Ital Dermatol Venereol. 2013 Apr;148(2):217-23.
Cellulite is a very common skin alteration with a complex pathogenesis; different degrees of severity of cellulite can be observed in most part of people after puberty, and numerous cosmetic or more invasive treatments have been proposed, with variable efficacy. Since reproducible methods of evaluation of the effectiveness of cellulite treatments are lacking, the purpose of our group was to define and set general testing principles for evaluating the efficacy of slimming products and treatments/remodeling methods for cellulite, to achieve a delineation of reliable and reproducible research steps following a well-designed and scientifically valid methodology. After a careful review of literature and textbooks and according to personal experience, we defined assessment protocols based on clinical and instrumental tools. In order to make studies reliable, reproducible and safe, a protocol standardization is needed. The sponsor is responsible for assuring quality and information concerning the product under investigation; moreover, investigators should be experienced on cellulite evaluation and treatment, and, finally, the duration and modalities of application of the product should be specified. A treated VS non treated area comparison can be performed, to evaluate the severity of cellulite and the clinical outcomes of the treatment. Besides clinical evaluation, instrumental methods should always be implemented to provide objective data for treatment outcome.
脂肪团是一种非常常见的皮肤改变，其发病机制复杂；大多数人在青春期后都会出现不同程度的脂肪团，为此已经提出了许多美容或更具侵入性的治疗方法，但疗效不一。由于缺乏评估脂肪团治疗效果的可重复性方法，我们小组的目的是定义和设定一般的测试原则，以评估减肥产品和治疗/重塑脂肪团的方法的功效，从而按照精心设计和具有科学有效性的方法学来制定可靠和可重复的研究步骤。在仔细审查文献和教科书并根据个人经验后，我们根据临床和仪器工具定义了评估方案。为了使研究可靠、可重复和安全，需要进行方案标准化。发起人负责保证所研究产品的质量和信息；此外，研究者应该具有脂肪团评估和治疗方面的经验，最后，还应该具体说明产品的应用持续时间和方式。可以进行治疗与未治疗区域的比较，以评估脂肪团的严重程度和治疗的临床效果。除了临床评估外，还应始终采用仪器方法，为治疗效果提供客观数据。
