Jackson Robert F, Roche Gregory C, Shanks Steven C
Surgeon's, Inc., Marion, Indiana 46952, USA.
Lasers Surg Med. 2013 Mar;45(3):141-7. doi: 10.1002/lsm.22119.
Cellulite is present in 90% of post-adolescent women. Several technologies have been developed for treating cellulite; however, they all involve some degree of massage or mechanical manipulation. The purpose of this study was to assess the effectiveness of a low-level laser light device employing green 532 nm diodes as a stand-alone procedure without massage or mechanical manipulation for improving the appearance of cellulite in the thighs and buttocks.
STUDY DESIGN/MATERIALS AND METHODS: This double-blind study randomized subjects to undergo treatment with the LLLT device (N = 34) or sham treatment (N = 34). During a 2-week treatment phase, each subject received three weekly treatment sessions 2-3 days apart. During each session, the front and back of the hips, thighs, and waist were exposed for 15 minutes (30 minutes total).
Nineteen subjects in the LLLT group achieved a decrease of one or more stages on the Nurnberger-Muller grading scale (55.88%) versus three subjects (8.82%) in the sham-treated group (P < 0.0001). Two LLLT-treated subjects achieved 2-stage improvements on the Nurnberger-Muller Scale at the 2-week study endpoint and four did at the 6-week follow-up evaluation versus none of the sham-treated subjects at either time point. Subjects treated with LLLT achieved a significant decrease in combined baseline thigh circumference at the 2-week study endpoint and 6-week follow-up evaluation (for each, p < 0.0001 vs. baseline) versus no change for sham-treated subjects. LLLT-treated subjects also showed significant decreases in mean baseline body weight (P < 0.0005), BMI (P < 0.001), and percent BSA affected by cellulite (P < 0.0005) versus no change for any parameter among sham-treated subjects. Most LLLT-treated subjects (62.1%) were Very Satisfied or Somewhat Satisfied with the improvement in cellulite they received versus 25.8% of sham-treated subjects. There were no reports of adverse events.
Low-level laser therapy using green 532 nm diodes is safe and effective for improving the appearance of cellulite in the thighs and buttocks. In contrast with other technologies, LLLT is effective as a stand-alone procedure without requiring massage or mechanical manipulation. Future studies will assess the long-term benefits of LLLT for the treatment of cellulite.
90%的青春期后女性存在橘皮组织。已开发出多种治疗橘皮组织的技术；然而，它们都涉及一定程度的按摩或机械操作。本研究的目的是评估一种采用绿色532纳米二极管的低强度激光装置作为一种无需按摩或机械操作的独立治疗方法，用于改善大腿和臀部橘皮组织外观的有效性。
研究设计/材料与方法：这项双盲研究将受试者随机分为接受低强度激光治疗装置治疗组（N = 34）或假治疗组（N = 34）。在为期2周的治疗阶段，每个受试者每隔2 - 3天接受三次每周一次的治疗。每次治疗时，臀部、大腿和腰部的前后部位暴露15分钟（共30分钟）。
低强度激光治疗组中有19名受试者（55.88%）在纽伦堡 - 米勒分级量表上降低了一个或多个等级，而假治疗组中有3名受试者（8.82%）降低了等级（P < 0.0001）。在为期2周的研究终点，有2名接受低强度激光治疗的受试者在纽伦堡 - 米勒量表上有2级改善，在6周的随访评估中有4名受试者有2级改善，而假治疗组在这两个时间点均无受试者有此改善。在为期2周的研究终点和6周的随访评估中，接受低强度激光治疗的受试者的大腿基线周长总和显著降低（与基线相比，每次P < 0.0001），而假治疗组受试者无变化。接受低强度激光治疗的受试者的平均基线体重、BMI以及受橘皮组织影响的体表面积百分比也显著降低（P < 0.0005、P < 0.001、P < 0.0005），而假治疗组的任何参数均无变化。大多数接受低强度激光治疗的受试者（62.1%）对所接受的橘皮组织改善情况非常满意或有些满意，而假治疗组受试者的这一比例为25.8%。未报告不良事件。
使用绿色532纳米二极管的低强度激光疗法对于改善大腿和臀部橘皮组织的外观是安全有效的。与其他技术相比，低强度激光疗法作为一种独立的治疗方法有效，无需按摩或机械操作。未来的研究将评估低强度激光疗法治疗橘皮组织的长期益处。
