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骨质疏松症及其治疗对口腔健康的影响。

Impact of osteoporosis and its treatment on oral health.

机构信息

Department of Periodontics and Community Dentistry (SA, RSP, HSA), College of Dentistry, King Saud University, Riyadh, Saudi Arabia; People's Dental Academy (KPK), Bhopal, India; and People's College of Dental Sciences & Research Centre (PSA), Bhopal, India.

出版信息

Am J Med Sci. 2013 Nov;346(5):396-401. doi: 10.1097/MAJ.0b013e31828983da.

Abstract

Osteoporosis has emerged as a major health problem affecting middle-aged and older individuals. It is characterized by a reduced bone mass and strength, resulting in increased susceptibility to fractures. The disease is associated with several risk factors, and increasing evidence suggests that it may be associated with oral health conditions such as periodontal disease, reduced jaw bone density and tooth loss. Besides the effects of osteoporosis on oral health, bisphosphonate-related osteonecrosis of the jaws is a major concern to the dentist. Bisphosphonate-related osteonecrosis of the jaws is a recently described adverse effect of bisphosphonate therapy. The exact mechanisms by which these drugs cause necrosis of the jaws remain unclear, and a true cause-and-effect relationship between osteonecrosis of the jaw and bisphosphonate use has not yet been established. Hence, any form of invasive dentoalveolar treatment should be performed with caution in patients taking bisphosphonates. This review discusses current evidence on osteoporosis and its treatment implications as a risk factor in the development of various oral diseases.

摘要

骨质疏松症已成为影响中老年人的主要健康问题。其特征是骨量和骨强度减少,导致骨折易感性增加。该疾病与多种危险因素有关,越来越多的证据表明,它可能与口腔健康状况有关,如牙周病、颌骨密度降低和牙齿缺失。除了骨质疏松症对口腔健康的影响外,双膦酸盐相关性颌骨坏死也是牙医关注的主要问题。双膦酸盐相关性颌骨坏死是双膦酸盐治疗的一种新描述的不良反应。这些药物引起颌骨坏死的确切机制尚不清楚,颌骨坏死与双膦酸盐使用之间的真正因果关系尚未建立。因此,在接受双膦酸盐治疗的患者中,任何形式的侵袭性牙槽治疗都应谨慎进行。本文综述了骨质疏松症及其治疗意义作为各种口腔疾病发展的危险因素的现有证据。

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