抗吸收药物治疗骨质疏松症患者的唾液组成和性质。

Composition and Properties of Saliva in Patients with Osteoporosis Taking Antiresorptive Drugs.

机构信息

Department of Maxillofacial Surgery, Medical University of Gdansk, 80-210 Gdansk, Poland.

Department of Conservative Dentistry, Medical University of Gdansk, 80-210 Gdansk, Poland.

出版信息

Int J Environ Res Public Health. 2023 Feb 28;20(5):4294. doi: 10.3390/ijerph20054294.

DOI:10.3390/ijerph20054294

PMID:36901300

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10002130/

Abstract

UNLABELLED

The aim of this study was to examine how the composition and properties of saliva change in people with osteoporosis who have received antiresorptive (AR) treatment, compared to patients with osteoporosis who have not yet received this treatment.

METHODS

The study population consisted of 38 patients with osteoporosis using AR drugs (Group I) and 16 patients with osteoporosis who had never used AR drugs (Group II). The control group consisted of 32 people without osteoporosis. Laboratory tests included determination of pH and concentrations of Ca, PO, total protein, lactoferrin, lysozyme, sIgA, IgA, cortisol, neopterin, activity of amylase at rest, and stimulated saliva. The buffering capacity of stimulated saliva was also determined.

RESULTS

There were no statistically significant differences between the saliva of Group I and Group II. No statistically significant correlation was found between the amount of time using AR therapy (Group I) and the tested parameters of the saliva. Significant differences were found between Group I and the control group. The concentrations of PO, lysozyme, and cortisol were higher, while concentrations of Ca ions, sIgA, and neopterin were lower, in comparison to the control group. The significant differences between Group II and the control group were smaller, and they concerned only the concentrations of lysozyme, cortisol, and neopterin.

CONCLUSIONS

The saliva of people with osteoporosis subjected to AR therapy and those not subjected to AR therapy did not show statistically significant differences in terms of the examined parameters of the saliva. However, the saliva of patients with osteoporosis taking and not taking AR drugs was significantly different compared to the saliva of the control group.

摘要

目的

本研究旨在探讨接受抗吸收（AR）治疗的骨质疏松症患者与未接受该治疗的骨质疏松症患者的唾液组成和性质变化。

方法

研究人群包括 38 名使用 AR 药物的骨质疏松症患者（I 组）和 16 名从未使用 AR 药物的骨质疏松症患者（II 组）。对照组由 32 名无骨质疏松症的人组成。实验室检测包括 pH 值和 Ca、PO、总蛋白、乳铁蛋白、溶菌酶、sIgA、IgA、皮质醇、新蝶呤、休息时和刺激唾液中淀粉酶的活性。还测定了刺激唾液的缓冲能力。

结果

I 组和 II 组之间的唾液无统计学差异。未发现 AR 治疗时间（I 组）与唾液的测试参数之间存在统计学相关性。I 组与对照组之间存在显著差异。PO、溶菌酶和皮质醇的浓度较高，而 Ca 离子、sIgA 和新蝶呤的浓度较低。与对照组相比，II 组与对照组之间的差异较小，仅涉及溶菌酶、皮质醇和新蝶呤的浓度。