Matos A C, Souza G G, Moreira V, Ramalho A
Department of Social and Applied Nutrition, Institute of Nutrition, Center for Health Sciences, Center for Research on Micronutrients, NPqM, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Nutr Hosp. 2012 Nov-Dec;27(6):1981-6. doi: 10.3305/nh.2012.27.6.5891.
Vitamin A and zinc are powerful antioxidants with synergy between them, thus protecting the organism against oxidative stress during the pre and postoperative periods. Our aim was to investigate the evolution clinical in patients undergoing coronary artery bypass grafting while receiving vitamin A supplements according to their zinc nutritional status. They were randomly divided into two groups (2:1): Control group (G1 = 60); and Supplemented group (G2 = 30) and subdivided according to the nutritional status of zinc. Serum concentrations of retinol, β-carotene, zinc and levels of malondialdehyde were measured prior to (T0) and on the 21st day (T1) following surgery. After surgery, was found a significant difference between G1 and G2 when comparing retinol (G1 = 38.7 ± 17.1 μg/dL and G2 = 62.1 ± 20.3 μg/dL; p < 0.001) and β-carotene (G1 = 12.3 ± 5.7 μg/dL and G2 = 53.5 ± 20.9 μg/dL; p < 0.001) in the patients with adequate concentrations of zinc. Analyzing the evolution clinical, operative mortality was 8.33% in G1 and 3.33% in G2. Hospitalization time significantly smaller in the G2 was found in the patients who had adequate concentrations of zinc (p = 0.001), as well as time in the intensive care unit both in those with adequate and inadequate levels of zinc (p = 0.047; p = 0.039). Such results may indicate that vitamin A supplementation may have a positive impact in combating the oxidative stress to which these patients are exposed above all in patients with adequate levels of zinc.
维生素A和锌都是强大的抗氧化剂，它们之间具有协同作用，从而在术前和术后期间保护机体免受氧化应激。我们的目的是研究在接受冠状动脉搭桥术的患者中，根据其锌营养状况补充维生素A时的临床进展。他们被随机分为两组（2:1）：对照组（G1 = 60）；补充组（G2 = 30），并根据锌的营养状况进一步细分。在手术前（T0）和手术后第21天（T1）测量血清视黄醇、β-胡萝卜素、锌浓度和丙二醛水平。手术后，在锌浓度充足的患者中比较视黄醇（G1 = 38.7 ± 17.1 μg/dL，G2 = 62.1 ± 20.3 μg/dL；p < 0.001）和β-胡萝卜素（G1 = 12.3 ± 5.7 μg/dL，G2 = 53.5 ± 20.9 μg/dL；p < 0.001）时，发现G1和G2之间存在显著差异。分析临床进展，G1的手术死亡率为8.33%，G2为3.33%。在锌浓度充足的患者中，发现G2的住院时间显著缩短（p = 0.001），在锌水平充足和不足的患者中，重症监护病房的时间也显著缩短（p = 0.047；p = 0.039）。这些结果可能表明，补充维生素A可能对对抗这些患者所面临的氧化应激有积极影响，尤其是在锌水平充足的患者中。
