da Silva R, dos Santos-Valente E C, Burim Scomparini F, Saccardo Sarni R O, Costa-Carvalho B T
Federal University of Sao Paulo, Sao Paulo, SP, Brazil; Federal University of Alfenas, Alfenas, MG, Brazil.
Federal University of Sao Paulo, Sao Paulo, SP, Brazil.
Allergol Immunopathol (Madr). 2014 Jul-Aug;42(4):329-35. doi: 10.1016/j.aller.2013.02.013. Epub 2013 Jun 14.
Ataxia-telangiectasia (A-T) is a rare and degenerative disease that leads to varying degrees of immunodeficiency, oxidative stress, and malnutrition. Vitamin A and zinc are essential for immune function and antioxidant defence.
To compare levels of retinol, beta carotene, and zinc in patients with ataxia-telangiectasia and healthy controls.
We performed a cross-sectional study with 14 AT patients and 14 healthy controls matched for age and gender. All participants underwent a nutritional and laboratory evaluation comprising concentrations of retinol, beta carotene, serum and erythrocyte zinc, malondialdehyde (MDA), T lymphocyte numbers (CD4(+) and CD8(+)) and immunoglobulin (IgA).
The AT patients showed high rates of malnutrition with reduced lean body mass when compared to the control group. However, the concentrations of MDA, retinol, beta carotene, and serum and erythrocyte zinc in AT patients were similar to those of the control group. The retinol levels presented a negative correlation with MDA and positive correlation with IgA serum level.
The AT patients assessed showed no change in nutritional status for vitamin A and zinc; however, they presented severe impairment in overall nutritional status observed and correlation between retinol with MDA and IgA.
共济失调毛细血管扩张症（A-T）是一种罕见的退行性疾病，会导致不同程度的免疫缺陷、氧化应激和营养不良。维生素A和锌对免疫功能和抗氧化防御至关重要。
比较共济失调毛细血管扩张症患者和健康对照者体内视黄醇、β-胡萝卜素和锌的水平。
我们进行了一项横断面研究，纳入了14例A-T患者和14名年龄及性别匹配的健康对照者。所有参与者均接受了营养和实验室评估，包括视黄醇、β-胡萝卜素、血清和红细胞锌、丙二醛（MDA）、T淋巴细胞数量（CD4(+)和CD8(+)）以及免疫球蛋白（IgA）的浓度。
与对照组相比，A-T患者营养不良发生率较高，瘦体重降低。然而，A-T患者的MDA、视黄醇、β-胡萝卜素以及血清和红细胞锌的浓度与对照组相似。视黄醇水平与MDA呈负相关，与血清IgA水平呈正相关。
所评估的A-T患者在维生素A和锌的营养状况方面没有变化；然而，他们在整体营养状况方面存在严重损害，且视黄醇与MDA和IgA之间存在相关性。
