Bhatt-Mehta V, Nahata M C
College of Pharmacy, Ohio State University, Columbus 43210.
J Perinatol. 1990 Jun;10(2):129-33.
Dopamine hydrochloride is widely used to increase blood pressure, cardiac output, and peripheral perfusion in critically ill newborn infants and children with shock and congestive heart failure. These patients often require numerous other intravenous drugs such as dobutamine, tolazoline, and theophylline concurrently, but have limited venous access. As a result, two or more of these drugs may be administered through the same intravenous site. The objective of our study was to determine the physical compatibility and chemical stability of dopamine with dobutamine, tolazoline, and theophylline using simulated conditions encountered in the neonatal intensive care unit. Dopamine, dobutamine, tolazoline, and theophylline were studied at concentrations of 120 mg/100 mL, 120 mg/100 mL, 400 mg/100 mL, and 400 mg/500 mL, respectively, in 5% dextrose injection. The flow rate of dopamine was 0.3 mL/h while all combination drugs were run at 1 mL/h. Aliquots were collected at hourly intervals for 5 hours. A simultaneous static experiment was also performed by mixing dopamine with each combination drug in a ratio of 1:3 and allowing these to stand at room temperature. Samples were obtained at 0.5-hour intervals for 3 hours. Each aliquot was inspected visually for any change in color and clarity and analyzed in triplicate for dopamine content using high performance liquid chromatographic technique with electrochemical detection. Linear regression analysis was performed on the mean values of dopamine concentrations to assess its degradation. Dopamine was found to be physically and chemically stable with dobutamine, tolazoline, and theophylline. Thus, dopamine can be infused concurrently with any of these drugs in 5% dextrose injected at frequently used concentrations in newborn infants.
盐酸多巴胺被广泛用于提高危重新生儿以及患有休克和充血性心力衰竭的儿童的血压、心输出量和外周灌注。这些患者常常同时需要多种其他静脉用药，如多巴酚丁胺、妥拉唑啉和茶碱，但静脉通路有限。因此，这些药物中的两种或更多种可能通过同一个静脉部位给药。我们研究的目的是利用新生儿重症监护病房中遇到的模拟条件，确定多巴胺与多巴酚丁胺、妥拉唑啉和茶碱的物理相容性和化学稳定性。分别在5%葡萄糖注射液中以120mg/100mL、120mg/100mL、400mg/100mL和400mg/500mL的浓度研究多巴胺、多巴酚丁胺、妥拉唑啉和茶碱。多巴胺的流速为0.3mL/h，而所有联合用药的流速为1mL/h。每隔1小时收集一次等分试样，共收集5小时。还进行了一项同步静态实验，将多巴胺与每种联合用药按1:3的比例混合，并使其在室温下静置。每隔0.5小时取样一次，共取样3小时。对每个等分试样进行外观检查，看颜色和澄清度是否有任何变化，并使用带电化学检测的高效液相色谱技术对多巴胺含量进行一式三份分析。对多巴胺浓度的平均值进行线性回归分析，以评估其降解情况。发现多巴胺与多巴酚丁胺、妥拉唑啉和茶碱在物理和化学上是稳定的。因此，在新生儿中，多巴胺可以与这些药物中的任何一种以常用浓度在5%葡萄糖注射液中同时输注。
