Department of Experimental Pathology, University of Bologna, via S. Giacomo 12, 40126 Bologna Italy.
Curr Pharm Des. 2013;19(9):1675-9.
Inflamm-aging, that is the age-associated inflammatory status, is considered one of the most striking consequences of immunosenescence, as it is believed to be linked to the majority of age-associated diseases sharing an inflammatory basis. Nevertheless, evidence is emerging that inflamm-aging is at least in part independent from immunological stimuli. Moreover, centenarians who avoided or delayed major inflammatory diseases display markers of inflammation. In this paper we proposed a reappraisal of the concept of inflamm-aging, suggesting that its pathological effects can be independent from the total amount of pro-inflammatory mediators, but they would be rather associated with the anatomical district and type of cells where they are produced and where they primarily act.
炎症性衰老，即与年龄相关的炎症状态，被认为是免疫衰老最显著的后果之一，因为它被认为与大多数具有炎症基础的与年龄相关的疾病有关。然而，有证据表明，炎症性衰老至少在一定程度上独立于免疫刺激。此外，避免或延迟发生重大炎症性疾病的百岁老人表现出炎症标志物。在本文中，我们重新评估了炎症性衰老的概念，提出其病理作用可能不依赖于促炎介质的总量，而是与其产生的解剖部位和类型的细胞以及它们主要作用的部位相关。
