LIMES Life and Medical Sciences, Laboratory of Molecular Brain Physiology and Behavior, University of Bonn, Bonn 53115, Germany.
J Cell Sci. 2013 Jun 15;126(Pt 12):2571-6. doi: 10.1242/jcs.120261. Epub 2013 Apr 16.
In Drosophila, Insulin-like peptide 2 (Dilp-2) is expressed by insulin-producing cells in the brain, and is secreted into the hemolymph to activate insulin signaling systemically. Within the brain, however, a more local activation of insulin signaling may be required to couple behavioral and physiological traits to nutritional inputs. We show that a small subset of neurons in the larval brain has high Dilp-2-mediated insulin signaling activity. This local insulin signaling activation is accompanied by selective Dilp-2 uptake and depends on the expression of the Imaginal morphogenesis protein-late 2 (Imp-L2) in the target neurons. We suggest that Imp-L2 acts as a licensing factor for neuronal IIS activation through Dilp-2 to further increase the precision of insulin activity in the brain.
在果蝇中,胰岛素样肽 2 (Dilp-2) 由大脑中的胰岛素产生细胞表达,并分泌到血淋巴中,从而全身激活胰岛素信号系统。然而,在大脑中,可能需要更局部的胰岛素信号激活,将行为和生理特征与营养输入联系起来。我们发现,幼虫大脑中的一小部分神经元具有高 Dilp-2 介导的胰岛素信号活性。这种局部胰岛素信号激活伴随着选择性的 Dilp-2 摄取,并依赖于靶神经元中 Imaginal morphogenesis protein-late 2 (Imp-L2) 的表达。我们认为,Imp-L2 作为一个许可因子,通过 Dilp-2 激活神经元 IIS,进一步提高了大脑中胰岛素活性的精度。