Noh Sujin, Na Sungjoon, Song Xinge, Hyun Seogang
Department of Life Science, Chung-Ang University, Seoul, Republic of Korea.
Anim Cells Syst (Seoul). 2025 Mar 17;29(1):31-40. doi: 10.1080/19768354.2025.2480150. eCollection 2025.
The Imaginal morphogenesis protein-Late 2 (Imp-L2) in is recognized as a functional homolog of the insulin-like growth factor (IGF) binding protein family. In this study, we report that Imp-L2 expression in germline cells during oogenesis simultaneously enhances both fecundity and lifespan in female . Loss of Imp-L2, either through knockout or germline-specific knockdown, resulted in decreased reproductive activity, as evidenced by reduced ovary size and fecundity, along with a higher proportion of infertile flies. Conversely, overexpression of Imp-L2 specifically in germline cells enhanced reproductive activity. Imp-L2 appears to regulate germline stem cell proliferation and differentiation independently of IGF signaling. Interestingly, germline-specific knockdown of shortened the lifespan of female flies, whereas its overexpression extended it. Thus, Imp-L2 expression in the germline promotes both reproductive activity and longevity, presenting an exception to the typical trade-off between reproduction and lifespan.
成虫盘形态发生蛋白-Late 2（Imp-L2）被认为是胰岛素样生长因子（IGF）结合蛋白家族的功能同源物。在本研究中，我们报道了卵子发生过程中生殖细胞中Imp-L2的表达同时提高了雌性果蝇的繁殖力和寿命。通过基因敲除或生殖细胞特异性敲低使Imp-L2缺失，导致生殖活性降低，卵巢大小和繁殖力降低以及不育果蝇比例更高证明了这一点。相反，Imp-L2在生殖细胞中的特异性过表达增强了生殖活性。Imp-L2似乎独立于IGF信号传导调节生殖干细胞的增殖和分化。有趣的是，生殖细胞特异性敲低Imp-L2缩短了雌性果蝇的寿命，而其过表达则延长了寿命。因此，生殖细胞中Imp-L2的表达促进了生殖活性和寿命，这是繁殖和寿命之间典型权衡的一个例外。
