Nishizaki T, Matsumata T, Kanematsu T, Yasunaga C, Sugimachi K
Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
J Surg Res. 1990 Jul;49(1):92-7. doi: 10.1016/0022-4804(90)90116-j.
To search for possible untoward effects of surgical manipulation of a malignant tumor, a series of experiments was carried out using VX2 carcinoma of rabbits. Fourteen days after inoculation of VX2 carcinoma into the liver, the rabbits were separated into two groups: Group I, manual manipulation during relaparotomy; and Group II, relaparotomy alone without manual manipulation of the tumor. After these procedures, the tumor was surgically removed and histologic examinations were made. The incidence of vascular permeation of liver tumor cells into the hepatic vein was significantly higher in Group I (P less than 0.01). On the 14th day after resection of the tumor, the number of metastatic nodules in the lungs was significantly increased in Group I (P less than 0.01). Survival time of rabbits after resection of tumor was significantly shorter in Group I (P less than 0.01). These results are taken to mean that manual manipulation of a tumor may well enhance metastasis.
为了探寻对恶性肿瘤进行手术操作可能产生的不良影响，利用兔VX2癌开展了一系列实验。将VX2癌接种至兔肝脏14天后，将兔分为两组：第一组，再次剖腹手术时进行手法操作；第二组，仅进行再次剖腹手术，不对手肿瘤进行手法操作。这些操作完成后，通过手术切除肿瘤并进行组织学检查。第一组肝肿瘤细胞向肝静脉的血管浸润发生率显著更高（P<0.01）。在肿瘤切除后的第14天，第一组肺内转移结节数量显著增加（P<0.01）。第一组兔肿瘤切除后的生存时间显著更短（P<0.01）。这些结果表明，对肿瘤进行手法操作很可能会促进转移。
