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巴西 HIV 阳性和 HIV 阴性结核病患者住院时间长短的相关因素。

Factors associated with length of hospital stay among HIV positive and HIV negative patients with tuberculosis in Brazil.

机构信息

Post-Graduate Program in Health, Society, and Endemic Diseases in the Amazon, Amazonas Federal University/Para Federal University/Leonidas & Maria Deane Institute (Fiocruz Foundation), Manaus, Amazonas, Brazil.

出版信息

PLoS One. 2013 Apr 12;8(4):e60487. doi: 10.1371/journal.pone.0060487. Print 2013.

Abstract

OBJECTIVE

Identify and analyze the factors associated to length of hospital stay among HIV positive and HIV negative patients with tuberculosis in Manaus city, state of Amazonas, Brazil, in 2010.

METHODS

Epidemiological study with primary data obtained from monitoring of hospitalized patients with tuberculosis in Manaus. Data were collected by interviewing patients and analyzing medical records, according to the following study variables age, sex, co-morbidities, education, race, income, lifestyle, history of previous treatment or hospitalization due to tuberculosis, treatment regimen, adverse reactions, smear test, clinical form, type of discharge, and length of hospital stay. The associated factors were identified through chi-square or t-Student test at a 5% significance level.

RESULTS

Income from 1 to 3 minimum wages (P = 0.028), pulmonary tuberculosis form (P = 0.011), negative smear test or no information in this regard (P = 0.014), initial 6-month treatment scheme (P = 0.029), and adverse drug reactions (P = 0.021) were associated to prolonged hospital stay in HIV positive patients.

CONCLUSION

We found out that although there were no significant differences in the length of hospital stay in HIV positive patients, all factors significantly associated to prolonged hospital stay occurred in this group of patients. This finding corroborates other studies indicating the severity of tuberculosis in HIV patients, which may also contribute to lengthen their hospital stay.

摘要

目的

在巴西亚马逊州首府玛瑙斯,确定并分析与 HIV 阳性和 HIV 阴性肺结核患者住院时间相关的因素。

方法

这是一项对玛瑙斯住院肺结核患者进行监测的原始数据的流行病学研究。通过访谈患者和分析病历收集数据,根据以下研究变量:年龄、性别、合并症、教育程度、种族、收入、生活方式、既往因肺结核接受治疗或住院的病史、治疗方案、不良反应、涂片检查、临床形式、出院类型和住院时间。通过卡方检验或 t 检验在 5%的显著性水平下确定相关因素。

结果

收入在 1 到 3 个最低工资之间(P=0.028)、肺结核肺部形式(P=0.011)、涂片检查阴性或无此信息(P=0.014)、初始 6 个月治疗方案(P=0.029)和药物不良反应(P=0.021)与 HIV 阳性患者的住院时间延长相关。

结论

我们发现,尽管 HIV 阳性患者的住院时间没有显著差异,但所有与住院时间延长显著相关的因素都发生在这组患者中。这一发现证实了其他研究表明 HIV 患者的肺结核严重程度,这也可能导致他们的住院时间延长。

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