Nelson D R, Buxton T B, Luu Q N, Rissing J P
Veterans Administration Medical Center, Augusta, GA 30910.
J Thorac Cardiovasc Surg. 1990 Jun;99(6):977-80.
The consequences of using surgical bone wax are not well studied. We evaluated the infection-promoting potential of sterile bone wax in a rat model of chronic Staphylococcus aureus osteomyelitis. The addition of bone wax greatly reduced the quantitative bacterial inoculum (log colony-forming units) required to establish chronic osteomyelitis in 50% and 100% of challenged animals. The 50% infection rate was reduced from log 6.9 to 2.6 and the 100% infection rate from 8.2 to 4.4, respectively (p less than 0.015, t test for parallelism). Separate experiments were done 10 to 30 minutes after inoculation with only log 6.4 staphylococci. Tibiae of animals that received bone wax yielded more organisms than those that did not (log 2.76 +/- 0.68 versus 1.72 +/- 0.94, p less than 0.01). At 24 hours quantitative colony counts were not significantly different whether animals received wax or not (log 5.02 +/- 0.42 versus 4.43 +/- 0.65, p greater than 0.09). These studies suggest that the routine surgical use of bone wax should be reassessed.
手术用骨蜡的后果尚未得到充分研究。我们在金黄色葡萄球菌慢性骨髓炎大鼠模型中评估了无菌骨蜡促进感染的可能性。添加骨蜡极大地降低了在50%和100%受攻击动物中引发慢性骨髓炎所需的定量细菌接种量（对数集落形成单位）。50%的感染率分别从6.9降至2.6，100%的感染率从8.2降至4.4（p<0.015，平行性t检验）。在仅接种6.4对数葡萄球菌后10至30分钟进行了单独实验。接受骨蜡的动物胫骨产生的微生物比未接受骨蜡的动物更多（2.76±0.68对数与1.72±0.94对数，p<0.01）。在24小时时，无论动物是否接受骨蜡，定量菌落计数均无显著差异（5.02±0.42对数与4.43±0.65对数，p>0.09）。这些研究表明，应重新评估骨蜡的常规手术用途。
