364D 型立克次体引起的一组焦痂相关性疾病，加利福尼亚。
Rickettsia spp. 364D causing a cluster of eschar-associated illness, California.
机构信息
From the *Children's Hospital & Research Center Oakland, Pediatric Infectious Diseases, Oakland; †California Department of Public Health, Center for Infectious Diseases, Richmond, CA; ‡Jiann-Ping Hsu College of Public Health, Georgia Southern University, Statesboro, GA; §Lake County Public Health Department, Lakeport; and ¶Contra Costa Public Health, Martinez, CA.
出版信息
Pediatr Infect Dis J. 2013 Sep;32(9):1036-9. doi: 10.1097/INF.0b013e318296b24b.
We describe the clinical course of the first 3 pediatric cases infected with Rickettsia spp. 364D. Although the pathogen was identified in California ticks decades ago, only recently have human cases been documented. Clinical features are generally mild, characterized by eschar, fever, headache, malaise and lymphadenopathy. Antigenic similarity among rickettsiae leads to cross-reactive antibody responses; definitive diagnosis requires molecular methods.
我们描述了首例 3 例感染 Rickettsia spp. 364D 的儿科病例的临床经过。尽管数十年前就在加利福尼亚的蜱虫中鉴定出了该病原体，但直到最近才记录到人类感染病例。临床特征通常较轻，表现为焦痂、发热、头痛、不适和淋巴结病。立克次体之间的抗原相似性导致交叉反应性抗体反应；明确诊断需要分子方法。
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