利用原发性损伤、血清和血凝块进行分子与血清学研究，获取俄罗斯阿尔泰山地区蜱传立克次体病的新证据。
New evidence on tick-borne rickettsioses in the Altai region of Russia using primary lesions, serum and blood clots of molecular and serological study.
作者信息
Granitov Vladimir, Shpynov Stanislav, Beshlebova Olga, Arsenjeva Irina, Dedkov Vladimir, Safonova Marina, Stukolova Olga, Pantjukhina Anna, Tarasevich Irina
机构信息
Altai State Medical University, Barnaul, 656038, RF, Altai, Barnaul, Lenina str., 40, Russia.
«N.F. Gamaleya FRCEM», Moscow, Russia.
出版信息
Microbes Infect. 2015 Nov-Dec;17(11-12):862-5. doi: 10.1016/j.micinf.2015.08.011. Epub 2015 Sep 3.
Tick-borne rickettsioses (TBRs) have similar clinical symptoms and can give serological cross-reaction. We firstly found that in the natural foci of North Asian tick typhus (NATT) in the Altai region of Russia, TBRs can be caused by two Rickettsia species: Rickettsia sibirica subsp. sibirica (causative agent of NATT) and Rickettsia heilongjiangensis. Rickettsial DNA was detected in primary lesions, serum samples and blood clots using real-time PCR. Therefore, each case of TBRs should be verified by using molecular typing. TBR caused by R. sibirica subsp. sibirica - NATT dominates on the territory of Altai region.
蜱传立克次体病（TBRs）具有相似的临床症状，并且会出现血清学交叉反应。我们首次发现，在俄罗斯阿尔泰地区的北亚蜱传斑疹伤寒（NATT）自然疫源地，TBRs可由两种立克次体引起：西伯利亚立克次体西伯利亚亚种（NATT的病原体）和黑龙江立克次体。使用实时PCR在原发性损伤、血清样本和血凝块中检测到立克次体DNA。因此，每例TBRs都应通过分子分型进行验证。由西伯利亚立克次体西伯利亚亚种引起的TBR——NATT在阿尔泰地区占主导地位。
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