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啮齿动物和非人类灵长类动物中风模型中灌注-扩散不匹配的磁共振成像

Magnetic resonance imaging of perfusion-diffusion mismatch in rodent and non-human primate stroke models.

作者信息

Duong Timothy Q

机构信息

South Texas Veterans Health Care System, Department of Veterans Affairs, San Antonio, TX, USA.

出版信息

Neurol Res. 2013 Jun;35(5):465-9. doi: 10.1179/1743132813Y.0000000211. Epub 2013 Apr 16.

Abstract

Stroke is a leading cause of death and long-term disability. Non-invasive magnetic resonance imaging (MRI) has been widely used for the early detection of ischemic stroke and the longitudinal monitoring of novel treatment strategies. Recent advances in MRI techniques have enabled improved sensitivity and specificity to detecting ischemic brain injury and monitoring functional recovery. This review describes recent progresses in the development and application of multimodal MRI and image analysis techniques to study experimental stroke in rats and non-human primates.

摘要

中风是导致死亡和长期残疾的主要原因。非侵入性磁共振成像(MRI)已被广泛用于缺血性中风的早期检测以及新治疗策略的纵向监测。MRI技术的最新进展提高了检测缺血性脑损伤和监测功能恢复的灵敏度和特异性。本综述描述了多模态MRI和图像分析技术在研究大鼠和非人类灵长类动物实验性中风方面的发展和应用的最新进展。

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