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翼状胬肉切除术联合结膜自体移植:真实的存活率统计。

Pterygium excision with conjunctival autograft: true survival rate statistics.

机构信息

Department of Ophthalmology, Tel Aviv Medical Center, 6 Weismann St., Tel Aviv, Israel.

出版信息

Cornea. 2013 Sep;32(9):1243-50. doi: 10.1097/ICO.0b013e31828ce09c.

Abstract

PURPOSE

To evaluate the factors influencing long-term survival rate (ie, probability of recurrence-free eye over time) after pterygium excision with conjunctival autograft.

METHODS

A retrospective cohort study was performed. All patients who underwent excision of pterygium and conjunctival autograft at a single institution by the same surgeon during the years from 1997 to 2008 were included. Preoperative and postoperative patient data were collected. The patients were invited for follow-up examinations performed by the surgeon, and the recurrence was analyzed using survival rate statistics.

RESULTS

There were 20 recurrences (20/176, 11.4%) during an average follow-up time of 34.4 ± 36.2 months (range, 0.03-129.7 months), with no apparent leveling of the graph. Using survival rate statistics, the estimated mean time to recurrence was 104.5 ± 4.9 months (95% confidence interval, 94.9-114.0 months). Patients younger than 30 years (P = 0.031) and grafts attached with thicker sutures (6/0-8/0, P = 0.005) were more prone to have recurrences. Thin (9/0 or 10/0) nylon and polyglactin sutures had similar results (P = 0.819). Interestingly, pterygia invading less into the cornea probably had more recurrences (P = 0.054). There was an average improvement of logarithm of the minimum angle of resolution from 0.26 (preoperative) to 0.19 (postoperative) (P < 0.014). There were no major complications.

CONCLUSIONS

Use of survival rate statistics is indicated because the potential for pterygium recurrence is continuous. Worse prognosis is expected for younger patients, use of thicker sutures and possibly in less invading pterygia.

摘要

目的

评估翼状胬肉切除联合结膜自体移植术后长期无复发生存率(即,一段时间内无复发的眼的概率)的影响因素。

方法

进行了一项回顾性队列研究。纳入 1997 年至 2008 年间由同一位外科医生在同一机构行翼状胬肉切除联合结膜自体移植术的所有患者。收集术前和术后患者数据。邀请患者进行外科医生进行随访检查,并使用生存分析统计分析复发情况。

结果

在平均 34.4 ± 36.2 个月(范围 0.03-129.7 个月)的随访期间,有 20 例(20/176,11.4%)复发,图形无明显趋平。使用生存分析统计,估计的复发中位时间为 104.5 ± 4.9 个月(95%置信区间 94.9-114.0 个月)。小于 30 岁的患者(P=0.031)和使用较粗缝线缝合的移植物(6/0-8/0,P=0.005)更易复发。使用较细(9/0 或 10/0)尼龙和聚乳酸缝线的结果相似(P=0.819)。有趣的是,侵犯角膜较少的翼状胬肉可能有更多的复发(P=0.054)。术后最小分辨角对数视力平均提高 0.26(术前)至 0.19(术后)(P<0.014)。无重大并发症。

结论

由于翼状胬肉复发的可能性是连续的,因此需要使用生存分析统计。年轻患者、使用较粗缝线以及侵犯角膜较少的患者预后较差。

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