Faculty of Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.
Circ J. 2013;77(7):1854-61. doi: 10.1253/circj.cj-12-0916. Epub 2013 Apr 17.
Cold temperature has been reported to contribute to cardiovascular mortality, but it is not clear which people are more susceptible to cold temperature.
The relationship between ambient temperature and mortality was examined in 3,593 subjects from the Ibaraki Prefectural Health Study who died of cardiovascular disease during a mean follow-up period of 9.7±4.0 years. Daily values of meteorological variables were obtained from the Japan Meteorological Agency. Time-stratified case cross-over analysis was used. The multivariate odds ratios (ORs; 95% confidence interval) per 1°C decrease in daily maximum temperature over the day of death and the 2 days prior to this day adjusted for relative humidity were 1.018 (1.003-1.034) for all cardiovascular deaths and 1.025 (1.003-1.048) for stroke deaths. Risk-stratified analysis showed that younger subjects aged <80 years and those with hyperglycemia were more susceptible to cold temperature. The OR of all cardiovascular deaths related to cold temperature was 1.034 (1.012-1.056) for subjects aged <80 years, and that of stroke deaths was 1.076 (1.023-1.131) for those with hyperglycemia.
Exposure to cold temperature triggers cardiovascular deaths. Additionally, younger age and hyperglycemia could enhance susceptibility to cold temperature.
已有报道称寒冷的气温会导致心血管疾病死亡率上升，但目前尚不清楚哪些人更容易受到低温的影响。
本研究在 3593 名因心血管疾病死亡的茨城县居民（随访时间平均为 9.7±4.0 年）中，研究了环境温度与死亡率之间的关系。气象变量的日值由日本气象厅提供。采用时间分层病例交叉研究设计。多变量比值比（OR；95%置信区间）表示每日最高气温每降低 1°C，与死亡当天及其前 2 天的相对湿度调整后，所有心血管疾病死亡的 OR 为 1.018（1.003-1.034），卒中死亡的 OR 为 1.025（1.003-1.048）。分层分析显示，年龄<80 岁的年轻患者和伴有高血糖的患者更容易受到低温的影响。与低温有关的所有心血管疾病死亡的 OR 为 1.034（1.012-1.056），年龄<80 岁的患者中，卒中死亡的 OR 为 1.076（1.023-1.131），伴有高血糖的患者中。
暴露于寒冷温度会引发心血管疾病死亡。此外，年龄较小和高血糖可能会增加对低温的敏感性。
