通过静电相互作用形成胶束纳米粒子用于递送多核铂(II)药物。
Micellar nanoparticle formation via electrostatic interactions for delivering multinuclear platinum(II) drugs.
机构信息
Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, IN 46556, USA.
出版信息
Chem Commun (Camb). 2013 May 25;49(42):4809-11. doi: 10.1039/c3cc39119a.
PMID:23595166
Abstract
Nanoparticles formed via electrostatic interactions between methoxy-polyethylene glycol-block-poly(glutamic acid) (MPEG-PGA) and a multinuclear platinum(II) drug, di-cisPt, exhibit efficient platinum loading, improved cellular uptake, in vitro cytotoxicity, and enhanced in vivo efficacy.
摘要
通过甲氧基聚乙二醇嵌段聚谷氨酸（MPEG-PGA）与多核铂（II）药物顺铂的静电相互作用形成的纳米粒子具有高效的铂载量、提高的细胞摄取率、体外细胞毒性和增强的体内疗效。
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