The influence of nanocarrier architectures on antitumor efficacy of docetaxel nanoparticles.

To study the structural influence, hybrid amphiphilic copolymer (G2C) and linear amphiphilic copolymer (PEGC) were utilized to prepare docetaxel (DTX)-loaded nanoparticles through an antisolvent precipitation method. The different architectures of the hydrophilic portion affected the particle sizes significantly, and then induced the different antitumor activity. Compared with DTX/PEGC nanoparticles, the antitumor efficacy of DTX/G2C nanoparticles was significantly enhanced, the IC value was 2.1-fold lower , and the inhibition rate was 1.3-fold higher . These results suggested that the antitumor activity was significantly affected by the architecture of the nanocarriers, and should be considered when nanocarriers are designed.