Izumi Y, Clifford D B, Zorumski C F
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110.
Neurosci Lett. 1990 May 4;112(2-3):251-6. doi: 10.1016/0304-3940(90)90212-r.
The effects of the strychnine-insensitive glycine receptor antagonists, cycloleucine and 7-chlorokynurenic acid, on the induction of long-term potentiation (LTP) in CA1 of rat hippocampal slices were examined. A 5 min administration of cycloleucine (20-100 microM) or 7-chlorokynurenic acid (1-5 microM) during the delivery of high-frequency stimulation blocked the induction of LTP without affecting baseline synaptic transmission. Coapplication of 100 microM glycine with cycloleucine or 7-chlorokynurenic acid masked the inhibitory effect on the induction of LTP, supporting the hypothesis that these compounds act as glycine antagonists. These results indicate that glycine is a necessary factor for the induction of LTP in CA1 of the rat hippocampus.
研究了士的宁不敏感的甘氨酸受体拮抗剂环亮氨酸和7-氯犬尿氨酸对大鼠海马切片CA1区长期增强（LTP）诱导的影响。在高频刺激传递期间给予5分钟的环亮氨酸（20 - 100微摩尔）或7-氯犬尿氨酸（1 - 5微摩尔）可阻断LTP的诱导，而不影响基线突触传递。将100微摩尔甘氨酸与环亮氨酸或7-氯犬尿氨酸共同应用可掩盖对LTP诱导的抑制作用，支持这些化合物作为甘氨酸拮抗剂起作用的假说。这些结果表明甘氨酸是大鼠海马CA1区LTP诱导的必要因素。
