Bashir Z I, Tam B, Collingridge G L
Department of Pharmacology, School of Medical Sciences, University of Bristol, U.K.
Neurosci Lett. 1990 Jan 22;108(3):261-6. doi: 10.1016/0304-3940(90)90651-o.
The effects of 7-chlorokynurenate (7-C1KY) were examined on N-methyl-D-aspartate (NMDA) receptor-mediated synaptic mechanisms in the CA1 region of rat hippocampal slices. 7-C1KY depressed both the NMDA receptor-mediated component of synaptic transmission recorded in Mg2(+)-free medium and the induction of long-term potentiation (LTP) in Mg2(+)-containing medium. Both of these effects were reversed by D-serine, suggesting that the action of 7-C1KY was at the allosteric glycine site on the NMDA receptor.
研究了7-氯犬尿氨酸（7-C1KY）对大鼠海马切片CA1区N-甲基-D-天冬氨酸（NMDA）受体介导的突触机制的影响。7-C1KY既抑制了在无镁培养基中记录的NMDA受体介导的突触传递成分，也抑制了在含镁培养基中长时程增强（LTP）的诱导。这两种效应都被D-丝氨酸逆转，表明7-C1KY的作用位点是NMDA受体上的变构甘氨酸位点。
