Kuroda Satoshi
Department of Neurosurgery, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, Toyama, Japan.
Acta Neurobiol Exp (Wars). 2013;73(1):57-65. doi: 10.55782/ane-2013-1921.
In this article, the author reviews recent advancements of basic research on bone marrow stromal cell (BMSC) transplantation for ischemic stroke. The BMSCs are easily isolated from the patients themselves and transplanted into them without any ethical and immunological problem. Animal experiments have shown that BMSC transplantation significantly enhance the recovery of motor and/or cognitive function in various types of neurological disorders such as ischemic stroke. The transplanted BMSCs aggressively migrate toward the damaged tissue and proliferate in the host brain. The BMSCs significantly improve the neuronal receptor function and local glucose metabolism in the peri-infarct area when transplanted into the infarct brain. Recent studies strongly suggest that the BMSCs contain heterogeneous subpopulations and contribute to functional recovery through multiple mechanisms, including neuroprotection, inflammatory modulation, cell fusion, and neural differentiation. The author describes the importance to establish BMSC transplantation as a therapeutic entity that is scientifically proven.
在本文中，作者回顾了骨髓基质细胞（BMSC）移植治疗缺血性脑卒中基础研究的最新进展。骨髓基质细胞易于从患者自身分离，且移植过程不存在任何伦理和免疫问题。动物实验表明，骨髓基质细胞移植可显著促进各种类型神经疾病（如缺血性脑卒中）的运动和/或认知功能恢复。移植的骨髓基质细胞会积极向受损组织迁移并在宿主脑内增殖。当将骨髓基质细胞移植到梗死脑内时，它们能显著改善梗死灶周围区域的神经元受体功能和局部葡萄糖代谢。近期研究有力地表明，骨髓基质细胞包含异质性亚群，并通过多种机制促进功能恢复，这些机制包括神经保护、炎症调节、细胞融合和神经分化。作者阐述了将骨髓基质细胞移植确立为经科学验证的治疗手段的重要性。
