通过微透析法测定胆碱给药对清醒大鼠纹状体乙酰胆碱释放的影响。

Effect of choline administration on the release of acetylcholine from the striatum as determined by microdialysis in awake rats.

作者信息

Westerink B H, de Boer P

机构信息

University Centre for Pharmacy, Department of Medicinal Chemistry, Groningen, The Netherlands.

出版信息

Neurosci Lett. 1990 May 4;112(2-3):297-301. doi: 10.1016/0304-3940(90)90219-y.

DOI:10.1016/0304-3940(90)90219-y

PMID:2359529

Abstract

The release of acetylcholine from the striatum was recorded by an on-line microdialysis method during intraperitoneal administration of high doses of choline (1 mmol/kg). The effect of choline administration was also studied in rats in which the striatal release of acetylcholine was stimulated by atropine infusion. The results did not support the idea that the release of acetylcholine in the striatum is under the control of precursor availability.

摘要

在腹腔注射高剂量胆碱（1 mmol/kg）期间，通过在线微透析法记录纹状体中乙酰胆碱的释放。还在通过注入阿托品刺激纹状体乙酰胆碱释放的大鼠中研究了胆碱给药的效果。结果不支持纹状体中乙酰胆碱的释放受前体可用性控制这一观点。