锰的稳态与转运。
Manganese homeostasis and transport.
作者信息
Roth Jerome, Ponzoni Silvia, Aschner Michael
机构信息
Department of Pharmacology and Toxicology, University at Buffalo School of Medicine, 11 Cary Hall, Buffalo, NY, 14214, USA.
出版信息
Met Ions Life Sci. 2013;12:169-201. doi: 10.1007/978-94-007-5561-1_6.
Abstract
The review addresses issues pertinent to Mn accumulation and its mechanisms of transport, its neurotoxicity and mechanisms of neurodegeneration. The role of mitochondria and glia in this process is emphasized. We also discuss gene x environment interactions, focusing on the interplay between genes linked to Parkinson's disease (PD) and sensitivity to Mn.
摘要
本综述探讨了与锰积累及其转运机制、神经毒性和神经退行性变机制相关的问题。强调了线粒体和神经胶质细胞在这一过程中的作用。我们还讨论了基因与环境的相互作用，重点关注与帕金森病（PD）相关的基因与对锰的敏感性之间的相互作用。
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本文引用的文献
1
Characterization of metal ion-nucleic acid interactions in solution.
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2
The iron transporter ferroportin can also function as a manganese exporter.
Biochim Biophys Acta. 2012 Mar;1818(3):651-7. doi: 10.1016/j.bbamem.2011.12.002. Epub 2011 Dec 8.
3
Expression of divalent metal transporter 1 in primary hippocampal neurons: reconsidering its role in non-transferrin-bound iron influx.
J Neurochem. 2012 Jan;120(2):269-78. doi: 10.1111/j.1471-4159.2011.07578.x. Epub 2011 Nov 28.
4
Methods to detect and characterize metal ion binding sites in RNA.
Met Ions Life Sci. 2011;9:37-100. doi: 10.1039/9781849732512-00037.
5
Structural and catalytic roles of metal ions in RNA.
Met Ions Life Sci. 2011;9:vii-ix.
6
Role of manganese in neurodegenerative diseases.
J Trace Elem Med Biol. 2011 Dec;25(4):191-203. doi: 10.1016/j.jtemb.2011.08.144. Epub 2011 Oct 1.
7
Mechanisms of manganese-induced neurotoxicity in primary neuronal cultures: the role of manganese speciation and cell type.
Toxicol Sci. 2011 Dec;124(2):414-23. doi: 10.1093/toxsci/kfr234. Epub 2011 Sep 22.
8
Manganese nanoparticle activates mitochondrial dependent apoptotic signaling and autophagy in dopaminergic neuronal cells.
Toxicol Appl Pharmacol. 2011 Nov 1;256(3):227-40. doi: 10.1016/j.taap.2011.07.018. Epub 2011 Aug 5.
9
Manganese-induced single strand breaks of mitochondrial DNA in vitro and in vivo.
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10
DMT1 polymorphism and risk of Parkinson's disease.
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