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2
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本文引用的文献

1
Characterization of metal ion-nucleic acid interactions in solution.溶液中金属离子与核酸相互作用的表征
Met Ions Life Sci. 2012;10:1-42. doi: 10.1007/978-94-007-2172-2_1.
2
The iron transporter ferroportin can also function as a manganese exporter.铁转运蛋白也可作为锰的输出蛋白发挥作用。
Biochim Biophys Acta. 2012 Mar;1818(3):651-7. doi: 10.1016/j.bbamem.2011.12.002. Epub 2011 Dec 8.
3
Expression of divalent metal transporter 1 in primary hippocampal neurons: reconsidering its role in non-transferrin-bound iron influx.二价金属转运蛋白 1 在原代海马神经元中的表达：重新考虑其在非转铁蛋白结合铁内流中的作用。
J Neurochem. 2012 Jan;120(2):269-78. doi: 10.1111/j.1471-4159.2011.07578.x. Epub 2011 Nov 28.
4
Methods to detect and characterize metal ion binding sites in RNA.检测和表征RNA中金属离子结合位点的方法。
Met Ions Life Sci. 2011;9:37-100. doi: 10.1039/9781849732512-00037.
5
Structural and catalytic roles of metal ions in RNA.金属离子在RNA中的结构和催化作用。
Met Ions Life Sci. 2011;9:vii-ix.
6
Role of manganese in neurodegenerative diseases.锰在神经退行性疾病中的作用。
J Trace Elem Med Biol. 2011 Dec;25(4):191-203. doi: 10.1016/j.jtemb.2011.08.144. Epub 2011 Oct 1.
7
Mechanisms of manganese-induced neurotoxicity in primary neuronal cultures: the role of manganese speciation and cell type.锰诱导原代神经元培养物神经毒性的机制：锰形态和细胞类型的作用。
Toxicol Sci. 2011 Dec;124(2):414-23. doi: 10.1093/toxsci/kfr234. Epub 2011 Sep 22.
8
Manganese nanoparticle activates mitochondrial dependent apoptotic signaling and autophagy in dopaminergic neuronal cells.锰纳米颗粒激活多巴胺能神经元细胞中线粒体依赖的凋亡信号和自噬。
Toxicol Appl Pharmacol. 2011 Nov 1;256(3):227-40. doi: 10.1016/j.taap.2011.07.018. Epub 2011 Aug 5.
9
Manganese-induced single strand breaks of mitochondrial DNA in vitro and in vivo.锰诱导的线粒体 DNA 体内和体外单链断裂。
Environ Toxicol Pharmacol. 2008 Sep;26(2):123-7. doi: 10.1016/j.etap.2007.12.009. Epub 2008 Feb 14.
10
DMT1 polymorphism and risk of Parkinson's disease.DMT1 多态性与帕金森病风险。
Neurosci Lett. 2011 Sep 1;501(3):128-31. doi: 10.1016/j.neulet.2011.07.001. Epub 2011 Jul 12.

锰的稳态与转运。

Manganese homeostasis and transport.

作者信息

Roth Jerome, Ponzoni Silvia, Aschner Michael

机构信息

Department of Pharmacology and Toxicology, University at Buffalo School of Medicine, 11 Cary Hall, Buffalo, NY, 14214, USA.

出版信息

Met Ions Life Sci. 2013;12:169-201. doi: 10.1007/978-94-007-5561-1_6.

DOI:10.1007/978-94-007-5561-1_6
PMID:23595673
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6542352/
Abstract

The review addresses issues pertinent to Mn accumulation and its mechanisms of transport, its neurotoxicity and mechanisms of neurodegeneration. The role of mitochondria and glia in this process is emphasized. We also discuss gene x environment interactions, focusing on the interplay between genes linked to Parkinson's disease (PD) and sensitivity to Mn.

摘要

本综述探讨了与锰积累及其转运机制、神经毒性和神经退行性变机制相关的问题。强调了线粒体和神经胶质细胞在这一过程中的作用。我们还讨论了基因与环境的相互作用，重点关注与帕金森病（PD）相关的基因与对锰的敏感性之间的相互作用。