Department of Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Am J Clin Pathol. 2013 May;139(5):599-604. doi: 10.1309/AJCPHSV7TV2WOJFE.
Among 31 benign cystic neoplasms of the pancreas diagnosed as mucinous cystadenomas, we identified 9 (29%) cases of nonmucinous cystadenomas with a pancreatobiliary phenotype and an ovarian-like stroma. Although both cystic tumors belong to the same family, they should be separated because their epithelial lining and cyst fluid are different. The lining cells of the nonmucinous cystadenomas consisted of a single layer of cuboidal cells, similar to the epithelial cells of the normal pancreatic ducts, and were not dysplastic (90%-100% of the lining cells). The cyst fluid was described as serous or clear. The remaining 22 classical mucinous cystadenomas, lined predominantly by mucinous and foveolar epithelium, revealed focal pancreatobiliary epithelium in 86% of the cases, and 6 pancreatic invasive mucinous cystadenocarcinomas failed to show pancreatobiliary differentiation. We believe that these nonmucinous cystadenomas of the pancreas represent a distinctive subset of cystic neoplasms of the pancreas that probably have no malignant potential.
在 31 例被诊断为黏液性囊腺瘤的胰腺良性囊性肿瘤中，我们发现有 9 例（29%）为具有胰胆管表型和卵巢样基质的非黏液性囊腺瘤。尽管这两种囊性肿瘤属于同一类，但它们应该分开，因为它们的上皮衬里和囊液不同。非黏液性囊腺瘤的衬里细胞由单层立方细胞组成，类似于正常胰腺导管的上皮细胞，没有发育不良（衬里细胞的 90%-100%）。囊液被描述为浆液性或清亮。其余 22 例典型的黏液性囊腺瘤，主要由黏液和陷窝上皮组成，在 86%的病例中发现有胰胆管上皮，而 6 例胰腺浸润性黏液囊腺癌未能显示胰胆管分化。我们认为这些胰腺的非黏液性囊腺瘤代表了胰腺囊性肿瘤的一个独特亚群，可能没有恶性潜能。
