Wang Jui, Chiu Wei-Hsiu, Chen Ran-Chou, Chen Fu-Li, Tung Tao-Hsin
Fu-Jen Catholic University, Taipei, Taiwan.
National Yang-Ming University, Taipei, Taiwan Central Clinic and Hospital, Taipei, Taiwan Jinan University, Guangzhou, China Hungchi Women & Children's Hospital, Taoyuan, Taiwan Qisda Corporation, Taipei, Taiwan.
Asia Pac J Public Health. 2015 Mar;27(2):NP1793-804. doi: 10.1177/1010539513483830. Epub 2013 Apr 17.
The authors sought to explore the prevalence and factors related to nonalcoholic fatty liver disease (NAFLD) among occupational population in Taipei, Taiwan. A total of 8347 healthy adults voluntarily admitted to annual physical check-up. Blood samples and ultrasound-proved fatty liver sonography results were collected. The results showed that the prevalence of NAFLD was 48.4% and revealed a statistically significant increase with increasing population age. Males exhibited a greater prevalence of NAFLD than did females (57.8% vs 32.4%, P < .001). Using multiple logistic regression analysis, in addition to male gender, older age, higher body mass index, higher aspartate aminotransferase level, higher alanine aminotransferase level, presence of hypertension, presence of hyperuricemia, presence of hypercholesterolemia, higher fasting plasma glucose, and presence of hypertriglyceridemia were the significant factors associated with NAFLD. The differences in occupational professions were revealed. In conclusion, occupational populations are asymptomatic, and the diagnosis of NAFLD should be considered with older age, hyperuricemia, higher aspartate aminotransferase level, higher alanine aminotransferase level, and metabolic risk factors.
作者试图探讨台湾台北职业人群中非酒精性脂肪性肝病（NAFLD）的患病率及相关因素。共有8347名健康成年人自愿参加年度体检。收集了血液样本和经超声证实的脂肪肝超声检查结果。结果显示，NAFLD的患病率为48.4%，且随着人群年龄的增加呈统计学显著上升。男性NAFLD的患病率高于女性（57.8%对32.4%，P <.001）。采用多因素logistic回归分析，除男性性别外，年龄较大、体重指数较高、天冬氨酸转氨酶水平较高、丙氨酸转氨酶水平较高、患有高血压、患有高尿酸血症、患有高胆固醇血症、空腹血糖较高以及患有高甘油三酯血症是与NAFLD相关的显著因素。职业差异也有体现。总之，职业人群通常无症状，对于NAFLD的诊断应考虑年龄较大、高尿酸血症、天冬氨酸转氨酶水平较高、丙氨酸转氨酶水平较高以及代谢危险因素。
