Huang Qingzhi, Yu Hana, Zhong Xin, Tian Ying, Cui Zhenhua, Quan Zhenyu
Department of Preventive Medicine, Medical College, Yanbian University, 977 Gongyuan Street, Yanji, 133000, Jilin, China.
Department of Nephrology, Yanbian University Hospital, 119 Juzi Street, Yanji, 133000, Jilin, China.
J Hum Hypertens. 2023 Apr;37(4):313-320. doi: 10.1038/s41371-022-00686-w. Epub 2022 Apr 11.
The association between hypertension and nonalcoholic fatty liver disease (NAFLD) is not completely understood. This study aimed to investigate the association between hypertension and hepatic ultrasound examination-diagnosed positive NAFLD in healthy people; to conduct a comprehensive meta-analysis combining the results of previous studies; to explore whether hypertension was a risk factor for NAFLD. This study included 2049 adults (male: 870 and female: 1179), aged ≥20 years, whose anthropometric parameters were measured to analyze the risk of hypertension on NAFLD. We also collected data from 11 cross-sectional studies relevant to this topic using PubMed, Embase, Web of Science, CNKI, Wanfang, and CQVIP from beginning till 31 August 2020 and combined it with our data for a meta-analysis to explore whether hypertension was a risk factor for NAFLD. After adjusting for confounding factors, the odds of NAFLD in hypertensive subjects was 1.473 (95%CI: 1.119-1.938). After combining with 10 selected studies, 42711 participants were enrolled in meta-analysis. Hypertension was a risk factor for NAFLD (Z = 13.46, P < 0.001); the odds of NAFLD in hypertensive subjects was 1.43 (95%CI: 1.36-1.51). The results were consistent with the results of the meta-analysis. Further studies are required to confirm these results.
高血压与非酒精性脂肪性肝病（NAFLD）之间的关联尚未完全明确。本研究旨在调查健康人群中高血压与肝脏超声检查诊断为阳性的NAFLD之间的关联；对既往研究结果进行综合荟萃分析；探讨高血压是否为NAFLD的危险因素。本研究纳入了2049名年龄≥20岁的成年人（男性870名，女性1179名），测量其人体测量学参数以分析高血压对NAFLD的风险。我们还使用PubMed、Embase、Web of Science、中国知网、万方和维普，收集了从开始至2020年8月31日与该主题相关的11项横断面研究的数据，并将其与我们的数据合并进行荟萃分析，以探讨高血压是否为NAFLD的危险因素。在调整混杂因素后，高血压患者发生NAFLD的比值比为1.473（95%置信区间：1.119 - 1.938）。与10项选定研究合并后，有42711名参与者纳入荟萃分析。高血压是NAFLD的危险因素（Z = 13.46，P < 0.001）；高血压患者发生NAFLD的比值比为1.43（95%置信区间：1.36 - 1.51）。结果与荟萃分析结果一致。需要进一步研究来证实这些结果。
