年龄对HIV-1疾病标志物的影响。
Impact of age on markers of HIV-1 disease.
作者信息
Pirrone Vanessa, Libon David J, Sell Christian, Lerner Chad A, Nonnemacher Michael R, Wigdahl Brian
机构信息
Department of Microbiology & Immunology, Drexel University College of Medicine, 245 N 15th Street, New College Building, Philadelphia, PA 19102, USA ; Drexel University College of Medicine, 245 N 15th Street, New College Building, Philadelphia, PA 19102, USA.
出版信息
Future Virol. 2013 Jan;8(1):81-101. doi: 10.2217/fvl.12.127.
Aging is a complicated process characterized by a progressive loss of homeostasis, which results in an increased vulnerability to multiple diseases. HIV-1-infected patients demonstrate a premature aging phenotype and develop certain age-related diseases earlier in their lifespan than what is seen in the general population. Age-related comorbidities may include the development of bone disease, metabolic disorders, neurologic impairment and immunosenescence. Age also appears to have an effect on traditional markers of HIV-1 disease progression, including CD4 T-cell count and viral load. These effects are not only a consequence of HIV-1 infection, but in many cases, are also linked to antiretroviral therapy. This review summarizes the complex interplay between HIV-1 infection and aging, and the impact that aging has on markers of HIV-1 disease.
衰老过程复杂，其特征是体内稳态逐渐丧失，这会导致机体对多种疾病的易感性增加。感染HIV-1的患者表现出早衰的表型，并且在其寿命中比普通人群更早地患上某些与年龄相关的疾病。与年龄相关的合并症可能包括骨病、代谢紊乱、神经功能障碍和免疫衰老。年龄似乎也会对HIV-1疾病进展的传统指标产生影响，包括CD4 T细胞计数和病毒载量。这些影响不仅是HIV-1感染的结果，而且在许多情况下还与抗逆转录病毒疗法有关。本综述总结了HIV-1感染与衰老之间的复杂相互作用，以及衰老对HIV-1疾病指标的影响。
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