25 羟维生素 D 和甲状旁腺激素与南非两个族群代谢综合征的关联。
The association of 25 hydroxyvitamin D and parathyroid hormone with metabolic syndrome in two ethnic groups in South Africa.
机构信息
Department of Chemical Pathology, National Health Laboratory Service and University of the Witwatersrand, Parktown, Johannesburg, South Africa.
出版信息
PLoS One. 2013 Apr 15;8(4):e61282. doi: 10.1371/journal.pone.0061282. Print 2013.
INTRODUCTION
Though inconsistent, a number of studies have shown an association between vitamin D (25(OH)D) status, parathyroid hormone (PTH) and the metabolic syndrome (Met S). These have largely been carried out in Caucasians or black subjects living in high income countries. There no data on the relationship of 25(OH)D and PTH status with Met S in populations resident in Africa. The aims of this study were to evaluate if there was an association of 25(OH)D or PTH with Met S in non-Caucasian populations in South Africa, and whether these molecules explained ethnic differences in the prevalence of Met S and its individual components.
METHODS
We measured anthropometry, serum 25(OH)D and PTH levels and the components of Met S, plus related metabolic variables, in 374 African and 350 Asian Indian healthy adults from the greater Johannesburg metropolitan area.
RESULTS
Met S was diagnosed in 29% of the African and 46% of the Asian Indian subjects (p<0.0001). Subjects with Met S had higher PTH than those without Met S, (p<0.0001), whilst 25(OH)D levels were not significantly different (p = 0.50). In multivariate analysis, 25(OH)D was not associated with any components of the Met S however PTH was shown to be positively associated with systolic (p = 0.018) and diastolic (p = 0.005) blood pressures and waist circumference (p<0.0001) and negatively associated with HOMA (p = 0.0008) levels. Logistic regression analysis showed that Asian Indian ethnicity (OR 2.24; 95% CIs 1.57, 3.18; p<0.0001) and raised PTH (OR 2.48; 95% CIs 1.01, 6.08; p = 0.04; adjusted for 25(OH)D) produced an increased risk of Met S but 25(OH)D did not (OR 1.25; 95% CI 0.67, 2.24; p = 0.48).
CONCLUSIONS
Plasma PTH but not 25(OH)D is an independent predictor of the Met S in African and Asian Indians in South Africa.
简介
尽管结果不一致，但许多研究表明维生素 D（25（OH）D）状态、甲状旁腺激素（PTH）和代谢综合征（Met S）之间存在关联。这些研究主要在白种人或居住在高收入国家的黑人中进行。目前还没有关于居住在非洲的人群中 25（OH）D 和 PTH 状态与 Met S 之间关系的数据。本研究旨在评估非白种人群中 25（OH）D 或 PTH 是否与南非的 Met S 相关，以及这些分子是否解释了 Met S 及其各个成分的种族差异。
方法
我们测量了 374 名非洲裔和 350 名印度裔健康成年人的人体测量学、血清 25（OH）D 和 PTH 水平以及 Met S 的成分，以及相关的代谢变量，这些成年人都来自约翰内斯堡大都市区。
结果
29%的非洲裔和 46%的印度裔受试者患有 Met S（p<0.0001）。患有 Met S 的受试者的 PTH 高于没有 Met S 的受试者（p<0.0001），而 25（OH）D 水平没有显著差异（p=0.50）。在多变量分析中，25（OH）D 与 Met S 的任何成分都没有关联，而 PTH 与收缩压（p=0.018）和舒张压（p=0.005）以及腰围（p<0.0001）呈正相关，与 HOMA（p=0.0008）水平呈负相关。Logistic 回归分析显示，印度裔种族（OR 2.24；95%CI 1.57，3.18；p<0.0001）和升高的 PTH（OR 2.48；95%CI 1.01，6.08；p=0.04；调整 25（OH）D）会增加 Met S 的风险，但 25（OH）D 不会（OR 1.25；95%CI 0.67，2.24；p=0.48）。
结论
在南非的非洲裔和印度裔人群中，血浆 PTH 而不是 25（OH）D 是 Met S 的独立预测因子。
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