维生素 D、甲状旁腺激素与代谢综合征——PORMETS 研究。
Vitamin D, parathyroid hormone and metabolic syndrome - the PORMETS study.
机构信息
Grupo de Estudo da Insulino-Resistência, Sociedade Portuguesa de Endocrinologia, Diabetes e Metabolismo, Lisboa, Portugal.
EPIUnit - Instituto de Saúde Pública da Universidade do Porto (ISPUP), Porto, Portugal.
出版信息
BMC Endocr Disord. 2017 Nov 17;17(1):71. doi: 10.1186/s12902-017-0221-3.
BACKGROUND
Vitamin D (VitD) and parathyroid hormone (PTH) play important roles in calcium metabolism and skeletal homeostasis. Estimates of the VitD status in several European countries show large variations between them. In addition, no national population-based estimate has been published. VitD and PTH may also play important roles in cardiovascular risk, which has been suggested to be associated with metabolic syndrome (MetS) and is very prevalent in Portugal. The goal of our study was to evaluate the prevalence of hypovitaminosis D and its determinants as well as PTH serum level determinants and associations of the 25-hydroxyvitamin D and PTH serum levels with MetS and its individual components in a sample of the Portuguese mainland population.
METHODS
PORMETS is a national cross-sectional study that includes a total sample of 4095 adults. A subsample, including 500 participants, was randomly selected for the present study. A structured questionnaire was administered to collect information on personal medical histories and socio-demographic and behavioral characteristics. Blood pressure and anthropometrics measurements were performed. Fasting venous samples were collected and PTH and 25-hydroxyvitamin D were measured. VitD adequacy was classified according to the Institute of Medicine, and MetS was classified according to the Joint Interim Statement recommendations. Multiple linear regression and unconditional logistic regression models were used to estimate the associations between the levels of PTH and 25-hydroxyvitamin D and with MetS and its individual components.
RESULTS
The prevalence of VitD deficiency was 37.7%, and MetS was present in 191 participants (38.4%). The serum PTH levels showed a positive association (OR: 1.014; 95%CI: 1.002, 1.026) with the waist circumference component of MetS. The serum 25-hydroxyvitamin D levels were negatively associated with MetS (OR: 0.957; 95%CI: 0.922, 0.993) as well as with its blood pressure (OR: 0.949; 95%CI: 0.912, 0.987) and triglycerides (OR: 0.930; 95%CI: 0.892, 0.969) components.
CONCLUSION
This study showed a high national prevalence of hypovitaminosis D. The PTH levels showed a significant positive association with the WC component of MetS, and the VitD levels were negatively associated with the BP and triglycerides components as well as with the MetS.
背景
维生素 D（VitD）和甲状旁腺激素（PTH）在钙代谢和骨骼平衡中发挥着重要作用。对几个欧洲国家的 VitD 状况的估计显示，它们之间存在很大差异。此外，也没有公布全国性的基于人群的估计值。VitD 和 PTH 也可能在心血管风险中发挥重要作用，而心血管风险与代谢综合征（MetS）有关，并且在葡萄牙非常普遍。我们的研究目的是评估葡萄牙大陆人群中 VitD 缺乏症的流行情况及其决定因素，以及 PTH 血清水平的决定因素，并评估 25-羟维生素 D 和 PTH 血清水平与 MetS 及其各个成分的关系。
方法
PORMETS 是一项全国性的横断面研究，共纳入了 4095 名成年人。其中一个包括 500 名参与者的子样本被随机选择用于本研究。通过问卷调查收集个人病史和社会人口学及行为特征信息。测量血压和人体测量学指标。采集空腹静脉血样，测量 PTH 和 25-羟维生素 D。根据医学研究所的标准对 VitD 充足性进行分类，根据联合临时声明的建议对代谢综合征进行分类。使用多元线性回归和非条件逻辑回归模型估计 PTH 和 25-羟维生素 D 水平与 MetS 及其各个成分之间的关系。
结果
VitD 缺乏症的患病率为 37.7%，有 191 名参与者（38.4%）患有 MetS。血清 PTH 水平与 MetS 的腰围成分呈正相关（OR：1.014；95%CI：1.002，1.026）。血清 25-羟维生素 D 水平与 MetS（OR：0.957；95%CI：0.922，0.993）以及血压（OR：0.949；95%CI：0.912，0.987）和甘油三酯（OR：0.930；95%CI：0.892，0.969）成分呈负相关。
结论
本研究显示葡萄牙全国范围内 VitD 缺乏症的高患病率。PTH 水平与 MetS 的 WC 成分呈显著正相关，VitD 水平与血压和甘油三酯成分以及 MetS 呈负相关。
Zotero 插件