Department of Urology, National Research Center for Sexual Medicine, Inha University School of Medicine, Incheon, Korea.
World J Mens Health. 2012 Aug;30(2):93-8. doi: 10.5534/wjmh.2012.30.2.93. Epub 2012 Aug 31.
The cavernous endothelium plays a crucial role in regulating the tone of the underlying smooth muscle and physiologic penile erection. Recently, the link between erectile dysfunction (ED) and cardiovascular disease was unveiled, and the main etiology of ED was found to be vasculogenic. Although oral phosphodiesterase-5 inhibitors are generally effective for men with ED, such therapies do not cure underlying vasculopathy in the corpus cavernosum tissue. This review addresses current preclinical protein, gene, and cell or stem cell therapies for enhancing cavernous endothelial regeneration and restoring erectile function.
海绵体的内皮在调节平滑肌张力和生理性阴茎勃起中起着至关重要的作用。最近，勃起功能障碍（ED）与心血管疾病之间的联系被揭示出来，ED 的主要病因被发现是血管源性的。虽然口服磷酸二酯酶-5 抑制剂通常对 ED 患者有效，但这些治疗方法并不能治愈海绵体组织中的潜在血管病变。本文综述了目前用于增强海绵体内皮再生和恢复勃起功能的临床前蛋白质、基因、细胞或干细胞治疗方法。
