质膜氧化还原与沉默调节蛋白的调控
Plasma membrane redox and control of sirtuin.
作者信息
Crane Frederick L, Low Hans
机构信息
Department of Biological Science, Purdue University, W. Lafayette, Indiana USA ; 610 Countryside Drive, Metamora, IL 61548 USA.
出版信息
Age (Dordr). 2005 Jun;27(2):147-52. doi: 10.1007/s11357-005-1631-0. Epub 2005 Dec 10.
We consider possible contributions of plasma membrane redox systems to Aging control by sirtuin (SIR). Reported changes in plasma membrane redox introduced by calorie restriction (CR) may lead to activation of SIR. The most obvious effect would lie in the increase of NAD+ as a result of NADH oxidation. So the question arises, do the observed changes herald an increase in NADH oxidase under CR? The other possibility is an increase in expression of SIR by activation of plasma membrane oxidase. Previous experiments have shown that activation of the plasma membrane redox system can increase cellular NAD+ concentration. The plasma membrane redox systems are also involved in control of protein kinase activity through oxygen radical generation. This activity may be related to control of SIR expression.
我们考虑了质膜氧化还原系统对由沉默调节蛋白（SIR）控制衰老的可能作用。热量限制（CR）引起的质膜氧化还原变化可能会导致SIR的激活。最明显的影响可能是由于NADH氧化导致NAD⁺增加。因此问题来了，在热量限制下观察到的这些变化是否预示着NADH氧化酶的增加呢？另一种可能性是通过质膜氧化酶的激活来增加SIR的表达。先前的实验表明，质膜氧化还原系统的激活可以增加细胞内NAD⁺浓度。质膜氧化还原系统还通过氧自由基的产生参与蛋白激酶活性的控制。这种活性可能与SIR表达的控制有关。
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