先天性弓形虫病的耳科病理学。
Otopathology in congenital toxoplasmosis.
机构信息
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA.
出版信息
Otol Neurotol. 2013 Aug;34(6):1165-9. doi: 10.1097/MAO.0b013e31828297b6.
OBJECTIVE
To describe the temporal bone histopathology in children with congenital toxoplasmosis.
BACKGROUND
Toxoplasmosis is a parasitic infection caused by Toxoplasma gondii. If fetal infection occurs early in gestation, severe inflammation and necrosis can cause brain lesions, chorioretinitis, and hearing loss. Hearing loss in congenital toxoplasmosis may be preventable with early diagnosis and treatment.
MATERIALS AND METHODS
The temporal bones of 9 subjects with congenital toxoplasmosis were removed at autopsy and studied under light microscopy. Cytocochleograms were constructed for hair cells, the stria vascularis, and cochlear neuronal cells.
RESULTS
Three (33%) of 9 subjects were found to have parasites in the temporal bone. The organism was identified in the internal auditory canal, the spiral ligament, stria vascularis, and saccular macula. The cystic form of the parasite was not associated with the inflammatory response seen in the active tachyzoite form.
CONCLUSION
We infer that the hearing loss of toxoplasmosis is likely the result of a postnatal inflammatory response to the tachyzoite form of T. gondii. Our findings have implications for the early identification and management of Toxoplasmosis.
目的
描述先天性弓形体病患儿的颞骨组织病理学变化。
背景
弓形体病是由刚地弓形虫引起的寄生虫感染。如果胎儿在妊娠早期感染，严重的炎症和坏死可导致脑损伤、脉络膜炎和听力损失。如果能早期诊断和治疗，先天性弓形体病导致的听力损失是可以预防的。
材料和方法
对 9 例先天性弓形体病患儿的颞骨进行尸检，在光镜下进行研究。为毛细胞、血管纹和耳蜗神经元细胞构建细胞鼓室图。
结果
在 9 例患者中有 3 例（33%）发现颞骨中有寄生虫。该生物体在内耳道、螺旋韧带、血管纹和囊斑中被识别。囊状寄生虫与活性速殖子形式的炎症反应无关。
结论
我们推断，弓形体病的听力损失可能是对刚地弓形虫速殖子形式的一种后天炎症反应所致。我们的研究结果对早期识别和管理弓形体病具有重要意义。
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