西维美林与毛果芸香碱对唾液分泌的疗效：一项初步研究。
Efficacy of cevimeline vs. pilocarpine in the secretion of saliva: a pilot study.
作者信息
Brimhall Jae, Jhaveri Malhar A, Yepes Juan F
机构信息
Orthodontics Resident, University of Kentucky College of Dentistry, Lexington, Kentucky, USA.
出版信息
Spec Care Dentist. 2013 May-Jun;33(3):123-7. doi: 10.1111/scd.12010. Epub 2013 Jan 7.
OBJECTIVES
To determine the efficacy and compare the side-effects of cevimeline and pilocarpine in the secretion of saliva in patients with xerostomia.
METHODS
A randomized, cross-over, double blind study was designed. Fifteen patients with diagnosis of xerostomia were assigned to take either 5 mg of pilocarpine or 30 mg of cevimeline three times a day for four weeks. Salivary flow rates were measured during the initial baseline, first and second month appointments. Statistical analysis was carried out with ANOVA and post hoc t-tests.
RESULTS
Twelve patients completed both medication treatments. Although both medications proved to increase salivary secretion, there was no significant difference between pilocarpine and cevimeline. Also, the perceived side-effects between the two medications were similar.
CONCLUSION
Both medications increased the secretion of saliva at the end of four weeks. However, there was a slightly higher increment in saliva with pilocarpine. However, the difference was not statistically significant.
目的
确定西维美林和毛果芸香碱对口干患者唾液分泌的疗效并比较其副作用。
方法
设计了一项随机、交叉、双盲研究。15名诊断为口干的患者被分配为每天服用3次5毫克毛果芸香碱或30毫克西维美林，持续4周。在初始基线、第一个月和第二个月就诊时测量唾液流速。采用方差分析和事后t检验进行统计分析。
结果
12名患者完成了两种药物治疗。虽然两种药物都被证明能增加唾液分泌，但毛果芸香碱和西维美林之间没有显著差异。此外，两种药物的感知副作用相似。
结论
两种药物在4周结束时均增加了唾液分泌。然而，毛果芸香碱使唾液增加的幅度略高。然而，差异无统计学意义。
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