Zhang Xiao-Lin, Ni Xiao-Chen, Jia Jin-Hai, Dong Jing-Hui, Yu Feng-Xue, Ma Ning, Liu Xue-Hui, Li Man, Liu Dian-Wu
Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Zhongshan East Road 361#, Shi Jiazhuang 050017, China.
Scand J Gastroenterol. 2013 Jun;48(6):736-44. doi: 10.3109/00365521.2013.787643. Epub 2013 Apr 22.
Owing to inconsistent observations in the literature of an association between HLA-DP polymorphisms (rs3077 and rs9277535) and hepatitis B virus (HBV) infection and spontaneous clearance, there is an urgent need for a comprehensive and reliable understanding of this subject. This meta-analysis was performed to quantitatively summarise the evidence for the relevance of these HLA-DP polymorphisms to HBV infection and spontaneous clearance.
A meta-analysis was conducted with the data from eight relevant papers published from April 2009 to March 2012, following strict selection. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for alleles, co-dominant, dominant and recessive genotype models of the rs3077 and rs9277535 loci.
Our analysis indicated a significant association of rs3077 and rs9277535 in HLA-DP with HBV infection, suggesting that these HLA-DP polymorphisms act beneficially against HBV infection (for rs3077, AG vs. GG: OR = 0.522, 95% CI = 0.485-0.561; AA vs. GG: OR = 0.350, 95% CI = 0.311-0.393; for rs9277535, AG vs. GG: OR = 0.542, 95% CI = 0.506-0.579; AA vs. GG: OR = 0.371, 95% CI = 0.336-0.409). Additionally, these HLA-DP polymorphisms served as protective factors in the spontaneous clearance of HBV (for rs3077, AG vs. GG: OR = 0.600, 95% CI = 0.464-0.775; AA vs. GG: OR = 0.420, 95% CI = 0.299-0.590; for rs9277535, AG vs. GG: OR = 0.623, 95% CI = 0.570-0.681 and AA vs. GG: OR = 0.464, 95% CI = 0.386-0.556) with similar results for both dominant and recessive genotype models.
Our results demonstrated that the rs3077 and rs9277535 HLA-DP polymorphisms reduced HBV infection and increased the likelihood of spontaneous viral clearance in some Asian populations.
鉴于文献中关于人类白细胞抗原-DP（HLA-DP）基因多态性（rs3077和rs9277535）与乙型肝炎病毒（HBV）感染及自发清除之间的关联存在不一致的观察结果，迫切需要对该主题有全面且可靠的认识。本荟萃分析旨在定量总结这些HLA-DP基因多态性与HBV感染及自发清除相关性的证据。
对2009年4月至2012年3月发表的八篇相关论文的数据进行严格筛选后进行荟萃分析。计算rs3077和rs9277535位点的等位基因、共显性、显性和隐性基因型模型的合并比值比（OR）及95%置信区间（CI）。
我们的分析表明，HLA-DP中的rs3077和rs9277535与HBV感染存在显著关联，提示这些HLA-DP基因多态性对HBV感染起有益作用（对于rs3077，AG与GG相比：OR = 0.522，95%CI = 0.485 - 0.561；AA与GG相比：OR = 0.350，95%CI = 0.311 - 0.393；对于rs9277535，AG与GG相比：OR = 0.542，95%CI = 0.506 - 0.579；AA与GG相比：OR = 0.371，95%CI = 0.336 - 0.409）。此外，这些HLA-DP基因多态性在HBV的自发清除中起保护作用（对于rs3077，AG与GG相比：OR = 0.600，95%CI = 0.464 - 0.775；AA与GG相比：OR = 0.420，95%CI = 0.299 - 0.590；对于rs9277535，AG与GG相比：OR = 0.623，95%CI = 0.570 - 0.681；AA与GG相比：OR = 0.464，95%CI = 0.386 - 0.556），显性和隐性基因型模型的结果相似。
我们的结果表明，rs3077和rs9277535 HLA-DP基因多态性在一些亚洲人群中降低了HBV感染并增加了病毒自发清除的可能性。
